Phase 2 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been newly diagnosed with multiple myeloma (a type of blood cancer), confirmed before any treatment began.
• You have already received a combination of three or four drugs to treat your myeloma, including at least two from these groups: immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and/or anti-CD38 drugs.
• After at least 4 rounds of that combination treatment, your cancer responded very well, but a very sensitive test still detected some remaining cancer cells.
• You are 18 years of age or older.
• You are generally able to care for yourself and are up and about for most of the day (your doctor can help assess this).
• Your blood counts, liver, and kidneys are working at an acceptable level, as shown by blood tests (your trial team will check this).
• If you are a woman who could become pregnant, you have had a negative pregnancy test before starting the trial.
• You are willing and able to use highly effective birth control during the trial and for 6 months after your last dose of the study treatment.
• You are willing and able to attend clinic visits and follow the study procedures.
• You are able to give written consent to take part.

Who may not be able to join:

• You have received other treatments for your myeloma beyond the initial combination therapy described above, including a stem cell transplant (your own or a donor's).
• You are currently taking part in another clinical trial using an investigational (experimental) drug.
• You have received a live vaccine within 4 weeks before your scheduled start of study treatment.
• You have a known allergy or serious reaction to any of the medications used in this trial.
• You are HIV-positive and also have a low immune cell count, a detectable level of HIV in your blood, are not on appropriate HIV treatment, or your HIV medication may interfere with the study drugs (confirm with trial site).
• You have an active hepatitis B infection, or testing shows hepatitis B virus is still present in your blood.
• You have an active hepatitis C infection (detectable virus in your blood), unless you have completed treatment for it and the virus is no longer detectable.
• You are a woman who is breastfeeding and are unwilling to stop during treatment or for 6 months after your last dose.
• You are unwilling to use highly effective contraception during the trial and for at least 6 months after your last dose.
• You have significant heart problems, such as severe heart failure, a heart attack or heart bypass surgery within the past 6 months, serious irregular heartbeat, or unstable heart disease.
• You have another serious uncontrolled illness, such as an active infection, active autoimmune disease, a blood clot condition, serious lung problems, or a psychiatric condition that could prevent you from following the study requirements.
• You have had another type of cancer requiring treatment within the past 12 months (some exceptions may apply — confirm with trial site).
• You have any other condition that, in the doctor's judgment, could put you at risk or prevent you from completing the trial.
• You are not able to make your own medical decisions.

Important: Always verify eligibility with the trial site directly before applying.