Phase 2 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender.
• People who have been diagnosed with pancreatic adenocarcinoma (a type of pancreatic cancer), either confirmed through a tissue or cell sample, or diagnosed based on scan results combined with a specific blood marker (CA 19-9) above a certain level.
• People whose pancreatic cancer is advanced — meaning it has spread or has not responded to treatment, and standard treatments are not expected to cure it.
• People whose cancer has continued to grow or spread after at least one previous cancer treatment, or who have chosen not to pursue standard treatment.
• People who stopped their previous pancreatic cancer treatment at least 14 days before the trial's starting visit.
• People whose cancer can be measured or assessed on scans using a standard medical measurement system (confirm with trial site).
• People who have had brain or spinal cancer spread in the past that has already been treated, provided the cancer is also present elsewhere in the body, there are no signs the brain/spinal condition has worsened since treatment, and there has been no history of bleeding in the brain or spine.
• People with a general health and activity level rated at 0, 1, or 2 on a standard medical scale (meaning able to carry out some daily activities, even if limited) (confirm with trial site).
• People whose blood test results before starting the trial meet specific requirements for white blood cell counts, platelet counts, kidney function, liver enzyme levels, bilirubin, and protein levels (confirm exact values with trial site).
• People with a life expectancy of at least 8 weeks.
• Women who could become pregnant must have a negative blood pregnancy test before joining.
• People who are willing and able to give written consent to participate.
• People who are willing to attend scheduled visits and follow the trial's requirements.

Who may not be able to join:

• People who have received systemic cancer treatment within 14 days before the starting visit, or who would be receiving it at the same time as the trial.
• People still experiencing side effects of grade 2 or higher from previous cancer treatment (with the exception of hair loss or a specific type of nerve-related side effect at grade 3).
• People who have had major surgery or radiation therapy within 14 days before the starting visit.
• People who have taken another experimental drug or treatment within 4 weeks (or within a specific timeframe based on that drug) before the starting visit.
• People taking certain medications that interact with a specific drug transport system in the body, unless those medications can be taken at least 3 hours apart from the trial drug (confirm with trial site).
• People who are unable to swallow tablets or capsules, or who have a digestive condition that may affect how the trial drug is absorbed.
• People with thyroid disease that is not well controlled, as assessed by the trial doctor.
• People currently being treated with medication, surgery, or radiation for an active bacterial, viral, or fungal infection.
• People with HIV/AIDS or other immune system deficiencies.
• People who have another active cancer (other than pancreatic adenocarcinoma) that is currently being treated.
• People with uncontrolled high blood pressure or significant heart failure.
• People who have experienced chest pain (angina), heart attack, stroke, certain bypass surgeries, a mini-stroke, or a blood clot in the lungs within the month before starting the trial.
• People with a history of, or current, heart rhythm problems requiring treatment, any degree of atrial fibrillation (an irregular heartbeat), or a consistently abnormal heart electrical reading on an ECG — unless the abnormality is due to a bundle branch block or a pacemaker.
• Women who are pregnant or breastfeeding.
• Women who could become pregnant and are unwilling to use two forms of contraception during the trial and for at least one month after finishing the trial drug.
• Men whose partner could become pregnant and who are unwilling to use two forms of contraception (including a condom) during the trial and for one month afterward.
• People with any serious medical or mental health condition, or abnormal test results, that in the trial doctor's opinion could increase the risks of participation, interfere with understanding the consent process, affect the ability to follow trial requirements, or affect the reliability of trial results.

Important: Always verify eligibility with the trial site directly before applying.