Parkinson's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been formally diagnosed with Parkinson's disease by a neurologist
• People with a mild to moderate stage of Parkinson's disease (not the most advanced stage)
• People who show signs of mild thinking or memory difficulties, based on a recognised cognitive screening score or confirmed by neuropsychological testing (either done as part of this trial or in the past 6 months elsewhere)
• People who take Parkinson's medication and have been on a stable, unchanged dose for at least one month before joining, and expect to stay on the same dose throughout the study

Who may not be able to join:

• People whose test results suggest dementia rather than mild cognitive difficulties
• People with severe depression, based on a standardised questionnaire score
• People with a psychotic disorder (except for certain mild hallucinations where the person is aware they are not real)
• People with signs of alcohol or drug misuse
• People with cardiac pacemakers, implanted defibrillators, implanted medication pumps, cochlear implants, or implanted neurostimulators — due to restrictions on the brain stimulation equipment used in this trial
• People with metal implants anywhere in the body — due to restrictions on both the brain stimulation and MRI procedures used in this trial
• People with broken, damaged, or irritated skin at the areas where stimulation would be applied
• People with large scars from reduced blood supply to tissue
• People who are pregnant, or women of childbearing age who do not confirm a negative pregnancy test before joining
• People with a personal history of epilepsy or seizures, or a family history of convulsions
• People with brain lesions that could affect the risk of seizures
• People with multiple sclerosis
• People currently taking certain medications, including some antidepressants, antipsychotics, or other drugs known to lower the threshold for seizures (confirm with trial site)
• People experiencing significant sleep deprivation during the study procedures
• People with severe heart disease or raised pressure inside the skull
• People with uncontrolled migraines
• People with unexplained episodes of loss of consciousness
• People with unstable or uncontrolled mental health conditions
• People with vascular clips or other electrically sensitive devices in the brain
• People with serious brain injury
• People with certain skin conditions such as dermatitis, psoriasis, or eczema
• People with severe or frequent headaches
• People with serious life-threatening illness, such as severe heart failure, chronic obstructive pulmonary disease, or active cancer
• People who have had previous brain surgery
• People who experienced a head injury that caused unconsciousness lasting at least one hour
• People with tattoos containing old metal-based ink, irremovable piercings, irremovable metal braces, or metal dental work — due to MRI requirements (confirm with trial site)
• People with claustrophobia or difficulty lying still for approximately 45 minutes
• People who have an abnormal growth or mass found on a brain MRI scan

Important: Always verify eligibility with the trial site directly before applying.