Depression and Anxiety Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to give their consent to take part in the research.
• People who are sufficiently fluent in English to understand and complete the study tasks.

Who may not be able to join:

• People who have metal objects inside their body (such as metal implants, vessel clips, or shrapnel) or implanted devices that could be harmed by a strong magnet (such as a pacemaker).
• People who have any other reason they cannot safely have an MRI scan, as identified through a safety screening process.
• People who have a history of, or are currently experiencing, a significant mental health condition (such as major depression).
• People who have ever been diagnosed with a significant personality disorder (such as borderline personality disorder), based on their own report.
• People diagnosed with ADHD or autism spectrum disorder where the condition significantly affects daily life, requires medication, or in the opinion of the study doctor could affect the reliability of the study results.
• People who are currently taking, or have taken within the last 3 months, any medications that affect the mind or mood (this would need further discussion with the research team).
• People who are currently using, or have used within the last 3 months, any medication that could interact with the study drug citalopram or affect the reliability of the study results.
• People who have a known reason they cannot take citalopram, including: a past allergic reaction to citalopram or similar medicines, a heart or cardiovascular condition, glaucoma, type 1 or type 2 diabetes, epilepsy, a previous diagnosis of angle-closure glaucoma, or currently taking any other medication that is known to interact with citalopram (such as those linked to a heart rhythm problem called prolonged QT-interval).
• People who have any current or past medical conditions that the study doctor believes could affect their safety or the reliability of the study results, including epilepsy or seizures, brain injury, liver or kidney disease, diabetes, severe digestive problems, brain tumours, or other neurological conditions.
• People whose urine drug screen, pulse, or blood pressure readings are outside a clinically acceptable range (though the study doctor may still consider some individuals on a case-by-case basis if the finding is unlikely to add risk or affect the study).
• People who currently have an alcohol or substance misuse disorder.
• People whose Body Mass Index (a measure of body weight relative to height) is below 18 or above 30.
• People who are pregnant, planning to become pregnant, or currently breastfeeding.
• People who have previously taken part in a study using similar computer tasks to those in this study (such as an MRI faces task or emotional test battery).
• People who have taken part in a study involving a mind- or mood-affecting medication or brain stimulation within the last three months.
• People who have used recreational drugs (such as cannabis, cocaine, or amphetamines) within the last three months.
• People who smoke more than 5 cigarettes per day, or who vape a comparable amount (more than 0.5ml, roughly a quarter of a 2ml vape, per day).
• People who typically drink more than 6 caffeinated drinks per day (such as tea, coffee, cola, or energy drinks).
• People who the study investigator believes are unlikely to follow the study procedures, or who are considered unsuitable for any other reason.

Important: Always verify eligibility with the trial site directly before applying.