Phase 2 Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are veterans and report moderate to severe chronic low back pain that has been present on most days for at least 3 months, with a pain score of at least 4 out of 10, and where the pain significantly interferes with daily life.
• People who are currently experiencing significant symptoms of depression, based on a score of 11 or higher on a standard depression questionnaire called the QIDS-SR.
• People who have been medically stable, meaning no hospital stays lasting 3 or more days in the past month.
• People whose pain or depression medications have not changed in the past 4 weeks.
• People who have no planned surgeries, injections, hospital stays, or new treatments for back pain (other than physical therapy or exercise) or depression in the next four months.
• People who have an adult available to drive them home after ketamine treatment sessions.

Who may not be able to join:

• People who are not able to speak English, as the study involves a program conducted in English.
• People who are unable or unwilling to sign a written consent form (for example, due to current confusion or disorientation).
• People who currently have psychotic symptoms, or who have a history of schizophrenia, schizoaffective disorder, or another psychotic disorder.
• People who are currently taking part in another clinical trial for pain or depression.
• People with uncontrolled high blood pressure (systolic above 160 mmHg and/or diastolic above 100 mmHg).
• People with known increased pressure in the brain or eye, or a brain artery aneurysm.
• People with a history of liver cirrhosis or an unstable heart condition, such as severe heart failure.
• People whose blood test results for certain liver, kidney, or thyroid markers fall significantly outside the normal range (confirm with trial site for specific values).
• People who test positive for pregnancy, or people of childbearing potential who are not using a birth control method.
• People with a known allergic sensitivity to any ingredient in the ketamine injection used in this trial.
• People who have previously had serious side effects from ketamine.
• People who test positive for non-prescribed substances (other than cannabis) on the day of a ketamine infusion session.
• People with a current or past history of ketamine misuse or abuse.

Important: Always verify eligibility with the trial site directly before applying.