Atrial Fibrillation Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 18 to 90 years old
- People who have been diagnosed with persistent or permanent atrial fibrillation (an irregular heart rhythm that doesn't go away on its own)
- People who received a CRT device (a type of heart pacemaker) or a specialised pacing device between 3 months and 5 years before the study starts
- People who have a blockage in the heart's natural electrical relay system (AV node), or who had a procedure to intentionally block it, between 3 months and 5 years before the study starts
- People whose heart pumping function is at least 50% (measured by a test called LVEF)
- People who have had a specific heart stress marker in their blood (NT-proBNP) measured above 400 pg/mL within the last 24 months
- People who have been diagnosed with heart failure, or who experience at least mild symptoms from it during everyday activity
- People who are able to give their own informed consent to participate
Who may not be able to join:
- People whose heart pumping function is below 50%
- People whose heart's electrical signal takes longer than 150 milliseconds to travel through the heart (wide QRS)
- People who have pacing only in the right side of the heart (isolated RV pacing)
- People with severe disease affecting the heart valves
- People with severe coronary artery disease, including those who had a heart attack or a procedure to open blocked heart arteries within the past year, those who experience any chest pain from heart disease, or those with severe blockages in major heart arteries that cannot be treated
- People with end-stage kidney failure requiring dialysis
- People with serious lung disease who require oxygen at home
- People with major mobility problems, such as being wheelchair-bound or unable to complete a six-minute walking test
- People who have a large number of irregular heartbeats originating from the lower chambers of the heart (more than 15% of all heartbeats)
- People who have been diagnosed with end-stage cancer
- People whose life expectancy is less than one year
- People who are receiving palliative or hospice care
- People diagnosed with hypertrophic cardiomyopathy (a condition where the heart muscle is abnormally thick)
- People with an uncorrected hole between the two lower chambers of the heart
- People with a condition where abnormal substances have built up in the heart muscle (infiltrative cardiomyopathy)
- People with uncontrolled high blood pressure, defined as blood pressure above 160/100 on two separate readings taken at least 15 minutes apart
- People with a very low level of haemoglobin (the protein in red blood cells that carries oxygen) below 7 g/dL
- People who are pregnant or who plan to become pregnant
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Athanasios Thomaides, MD, MedStar Health
Phone: 302-530-1873
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Exercise tolerance as measured by the Six-Minute Walk Test
Can't join this trial?
Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.