Early Phase 1 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years old or younger, of any gender
• People diagnosed with colorectal cancer that has spread to other parts of the body or has grown into nearby tissues, confirmed by a tissue or cell sample test
• People whose cancer can be measured on scans according to standard medical guidelines (RECIST version 1.1)
• People whose cancer has gotten worse despite standard treatments, who could not tolerate standard treatments, or who have chosen not to have standard treatment
• People whose blood counts and organ function results fall within the ranges required by the trial (covering blood cell levels, liver and kidney function, and blood clotting measures — confirm specific values with the trial site)
• People with a general health/activity score of 0, 1, or 2 on the ECOG scale (meaning able to carry out at least some daily activities)
• People who are able to have children and agree to use reliable contraception during the trial and for at least 12 weeks after the last treatment
• People who have not had any other adoptive immune cell therapy or stem cell therapy in the past two years
• People who are willing to take part and sign a written consent form

Who may not be able to join:

• People with a known history of allergic reactions to biological medicines or to any substances used in cell culture processes
• People who are pregnant or breastfeeding
• People with an expected survival of more than 3 months (confirm with trial site, as this criterion is unclear)
• People with an active infection that requires treatment throughout the body, or an infection that cannot be controlled
• People who still have side effects from previous cancer treatments that have not recovered to a mild level (grade 1 or lower), except for hair loss
• People with a history of serious heart or brain blood vessel conditions, including certain abnormal heart rhythms requiring medical intervention, a heart attack, heart failure, stroke, or other serious heart events within the past 6 months, significant heart function problems, or high blood pressure that remains poorly controlled despite treatment
• People with serious lung or lung blood vessel conditions, including those considered at high risk for blood clots in the veins, or those who need extra oxygen to maintain normal blood oxygen levels
• People with active or symptomatic cancer spread to the brain or the lining of the brain (people with stable brain spread may still be considered)
• People with a clinically confirmed autoimmune disease, except for thyroid inflammation
• People with HIV infection, or an active Epstein-Barr virus or cytomegalovirus infection
• People with active hepatitis B virus replication or hepatitis C infection
• People who have previously had a bone marrow transplant using donor cells
• People with a known immune deficiency, or those who need to take steroid medications above a certain dose or other immune-suppressing medications within 14 days before starting the trial or during the trial period (some short-term or preventive steroid use may be excepted — confirm with trial site)
• People with a known dependence on alcohol or drugs
• People whom the trial doctor considers unsuitable for full participation due to any other medical history, condition, treatment, or test result

Important: Always verify eligibility with the trial site directly before applying.