Phase 1 Mesothelioma Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have signed a consent form agreeing to take part in the study
- You are male or female and are 18 years old or older
- Your doctor expects you to live for at least 12 weeks
- You are generally able to carry out daily activities with little or no difficulty (this is measured using a standard scale called ECOG — confirm with trial site if unsure)
- (For the first part of the trial — dose escalation): You have been confirmed by lab testing to have advanced or spread mesothelioma, epithelioid hemangioendothelioma (EHE), or another advanced solid tumour, and your cancer has worsened after standard treatments, you could not tolerate those treatments, or standard treatments are not available or refused
- (For the second part of the trial — dose expansion): You have confirmed advanced or spread mesothelioma, EHE, or another advanced solid tumour with specific changes in a biological pathway called the "Hippo signalling pathway," and your cancer has worsened after standard treatments, you could not tolerate them, or they are not available or refused
- You have at least one tumour that can be measured on a scan
Who may not be able to join:
- You have previously used or are currently using a specific type of drug called a TEAD inhibitor
- You have not waited long enough after finishing your previous cancer treatments before joining (the required waiting period is set out in the trial rules — confirm with trial site)
- You have a severe or unstable serious illness, or you have cancer that has spread to the brain and is causing symptoms or is unstable
- You have significant heart or blood vessel problems as defined by the trial rules (confirm with trial site)
- You are pregnant or currently breastfeeding
- You have had an allergic reaction to the study drug (BGC515) or any of its ingredients
- You are a member of the trial staff, a close relative of a trial staff member, a direct report of the trial doctor, or an employee of the company running the trial
- You have other serious health conditions, abnormal lab results, or other issues that the trial doctor believes would make it unsafe or unsuitable for you to participate
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 408-498-8127
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Incidence of adverse events (AEs) and serious adverse events (SAEs).; Dose-limiting toxicities (DLTs); Objective response rate (ORR); Progress-free survival(PFS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.