Phase 2 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with locally advanced pancreatic cancer (cancer confirmed by tissue or cell testing).
• People whose pancreatic tumour measures less than 8.0 cm at its widest point at the time of treatment planning (final confirmation depends on meeting certain radiation safety limits for surrounding organs).
• People who are in generally good physical condition, able to carry out normal daily activities with little or no limitation (confirm with trial site for exact fitness level required).
• People whose doctor estimates they are expected to live for more than 6 months.
• People who have already received first-line chemotherapy for this cancer for at least 16 weeks without the cancer getting worse, and who have waited at least 2 weeks after finishing that chemotherapy before joining the trial.
• People who are able to understand the study information and are willing to sign a consent form.
• Women who are not pregnant or breastfeeding, and women who could potentially become pregnant must have a negative pregnancy test within 4 weeks before joining; women who are breastfeeding must stop before joining.

Who may not be able to join:

• People whose cancer has spread to other parts of the body (metastatic disease).
• People under 18 years of age.
• People who have previously received chemotherapy or any other anti-cancer treatment for cancer that had already spread to other parts of the body.
• People who have previously had radiation therapy to the upper abdomen area in a way that would overlap with the radiation planned for this trial.
• People who are currently receiving any anti-cancer treatment, including chemotherapy.
• People with serious uncontrolled health conditions such as active infection, severe heart failure, unstable chest pain, irregular heart rhythm, or mental health or social circumstances that would make it difficult to follow the study requirements.
• Women who are pregnant or breastfeeding.
• People with any other condition that, in the treating doctor's judgment, would make participation unsafe or difficult.
• People with a history of another type of cancer, unless they have been free of that cancer for at least 2 years and are considered low risk for it returning. An exception applies to people diagnosed and treated within the past 5 years for certain skin cancers (basal cell or squamous cell carcinoma) or early-stage cervical cancer (in situ), who may still be considered eligible.
• People with certain conditions that make high-dose targeted radiation unsafe, such as scleroderma (a connective tissue disease) or stomach or bowel ulcers or perforations in the area to be treated.
• People with conditions that are not compatible with MRI scanning, such as having a heart pacemaker, certain metal objects in the body, or severe claustrophobia. People who have previously had a severe allergic reaction to the MRI contrast agent gadolinium, or who have severe kidney disease (confirm with trial site for exact kidney function threshold), would also not be able to participate in the MRI component of this trial.

Important: Always verify eligibility with the trial site directly before applying.