Parkinson's Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
If you have been diagnosed with Parkinson's disease:
- You are a man or woman aged 30 or older at the time of your Parkinson's diagnosis
- You have at least two of these symptoms: shaking at rest, slowness of movement, or muscle stiffness — and at least one of those must be shaking or slowness; OR you have shaking or slowness on just one side of your body
- You were diagnosed with Parkinson's disease 2 years ago or less
- Your Parkinson's symptoms are mild to moderate (early stage, confirmed by a staging scale called Hoehn & Yahr, stage I or II)
- A special brain scan (called an AV133 PET scan) shows reduced activity of a protein called VMAT2 in your brain
- You have not yet started any Parkinson's medications
- You are able to give your consent to take part
If you are in the very early ("prodromal") stage before a formal Parkinson's diagnosis:
- You meet certain recognised early warning criteria for Parkinson's disease (confirm with trial site)
- You have been tested and confirmed to have a reduced sense of smell
- You have additional risk factors, such as a close biological relative with Parkinson's, a sleep condition called RBD, or a known gene variant linked to Parkinson's risk (such as LRRK2 or GBA)
- You are aged 60 or older — or aged 30 or older if you carry specific rare gene variants such as SNCA, Parkin, or Pink1
- A special brain scan (AV133 PET) shows reduced activity of the VMAT2 protein
- If you take certain medications (α-methyldopa, methylphenidate, amphetamine-based medicines, or modafinil), you are willing and able to stop taking them for a set period before your brain scan (confirm with trial site)
- You have not yet started any Parkinson's medications
- You are able to give your consent to take part
Who may not be able to join:
- You are currently taking any Parkinson's medications, such as levodopa, dopamine agonists, MAO-B inhibitors, or amantadine
- You have been diagnosed with dementia or a significant memory or thinking problem
- You have taken certain medicines within the past month that could interfere with the brain scan, including some antipsychotics, metoclopramide, reserpine, or stimulant-type medications (confirm full list with trial site)
- You have a significant heart condition, or an abnormal heart rhythm test result (ECG), including a specific reading called QTc above 450 ms
- You are currently taking any medicines known to affect heart rhythm (confirm with trial site)
- You have taken part in another clinical trial involving an experimental drug or device within the past 60 days
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 15811176880
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
to assess the mean rate of change and variability of AV133 imaging results
Can't join this trial?
Data last synced from ClinicalTrials.gov: 12 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.