Phase 2 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You (or your legal representative) are willing and able to sign a written consent form
• You are 18 years old or older at the time of signing consent
• You have been diagnosed with diffuse pleural mesothelioma (a type of cancer affecting the lining of the lungs), confirmed through a tissue sample
• You have already received at least one previous treatment for this cancer, such as platinum-based chemotherapy, pemetrexed, immunotherapy, or a combination of these
• Your cancer can be measured on scans using standard medical measurement guidelines
• You are willing to have a tissue biopsy taken before starting treatment and again at the start of the third treatment cycle, if it is safe and possible to do so
• You are in good enough general health to carry out daily activities (as measured by standard medical scoring tools) (confirm with trial site)
• Your blood counts, kidney function, liver function, and red blood cell levels meet the required levels shown in routine blood tests (confirm with trial site)
• If you are able to become pregnant, you must be willing to use a highly effective form of birth control for at least one month before, during, and for two months after treatment ends

Who may not be able to join:

• You are currently taking part in another clinical trial or have received an experimental treatment within the past 3 weeks
• You have previously had a severe allergic reaction to irinotecan or to any ingredients in the study drug sacituzumab govitecan-hziy
• You have received chemotherapy or immunotherapy within the last 3 weeks, or you are still experiencing significant side effects from a previous cancer treatment
• You have a psychiatric condition or substance use problem that, in the doctor's opinion, would make it difficult for you to take part in the trial
• You have another type of cancer that is growing or currently being treated (some early-stage or skin cancers may be exceptions — confirm with trial site)
• You currently have an active hepatitis B infection (some people with a past hepatitis B history may still be eligible — confirm with trial site)
• You currently have hepatitis C (people who have been successfully treated for hepatitis C may still be eligible — confirm with trial site)
• You are HIV-positive with certain conditions, such as a low immune cell count, a recent serious infection, or your HIV is not well controlled (confirm with trial site)
• You have had a heart attack, unstable chest pain, stroke, or heart bypass surgery within the past 6 months
• You have moderate to severe heart failure, or were hospitalised for heart failure within the past 6 months
• You are pregnant, breastfeeding, or able to become pregnant and are not using a highly effective form of birth control

Important: Always verify eligibility with the trial site directly before applying.