Depression and Anxiety Trial, Recruiting (NCT06488586)

Depression and Anxiety Trial, Recruiting NCT06488586 Sponsor: Gustavo Vazquez Condition: Depression and Anxiety

Printed from Voxsanity (voxsanity.com.au) — NCT06488586 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

Back to Depression And Anxiety

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

Adults between 18 and 75 years old who are being treated as outpatients (not admitted to hospital) and have been diagnosed with major depressive disorder (a serious form of depression) according to standard psychiatric guidelines (DSM-5)
People whose depression has not improved after trying at least two different antidepressant treatments at the right dose and for a long enough period of time during their current depressive episode

Who may not be able to join:

People who have psychosis (losing touch with reality), a primary diagnosis of a personality disorder, or high blood pressure that is not well controlled
People with a substance use or abuse problem
People who are currently pregnant or breastfeeding
People who have had a bad or negative reaction to ketamine or esketamine in the past
People who, for any reason, are not considered suitable to receive ketamine through an IV (into a vein) or esketamine as a nasal spray

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 26 July 2026

This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Gustavo H Vazquez, MD,PhD,FRCPC, Queen's University

Phone: +1 (613)-544-4900

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial which may be relevant to my care:

Trial: NCT06488586

Sponsor: Gustavo Vazquez

Phase: Not Applicable

Status: Recruiting

Condition: Depression and Anxiety

Trial contact: +1 (613)-544-4900

More information: https://clinicaltrials.gov/study/NCT06488586

Eligibility summary (AI generated)

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Adults between 18 and 75 years old who are being treated as outpatients (not admitted to hospital) and have been diagnosed with major depressive disorder (a serious form of depression) according to standard psychiatric guidelines (DSM-5)
People whose depression has not improved after trying at least two different antidepressant treatments at the right dose and for a long enough period of time during their current depressive episode

Who may not be able to join:

People who have psychosis (losing touch with reality), a primary diagnosis of a personality disorder, or high blood pressure that is not well controlled
People with a substance use or abuse problem
People who are currently pregnant or breastfeeding
People who have had a bad or negative reaction to ketamine or esketamine in the past
People who, for any reason, are not considered suitable to receive ketamine through an IV (into a vein) or esketamine as a nasal spray

Important: Always verify eligibility with the trial site directly before applying.

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 26 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Recruiting

Phase

Not Applicable

Sponsor

Gustavo Vazquez

Registry

ClinicalTrials.gov

Start date

20 March 2023

Est. completion

20 March 2026

Where this trial is recruiting

🇨🇦 Canada

Primary endpoints

Montgomery-Åsberg Depression Rating Scale (MADRS)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov