Phase 2 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with multiple myeloma (MM) confirmed according to recognised international guidelines.
• You are newly diagnosed with multiple myeloma and your doctors consider you suitable for high-dose chemotherapy and a stem cell transplant.
• You are generally able to carry out daily activities with little to no limitation (confirm with trial site).
• If you are HIV-positive, you may still be eligible if your HIV viral load is undetectable, your immune cell count is high enough, you have had no serious HIV-related infections in the past 6 months, and you are on stable HIV treatment.
• You are willing and able to sign a consent form showing you understand what the study involves.
• You are able and willing to follow the lifestyle rules set out in the study.
• If you are a woman who could become pregnant, you have had a negative pregnancy blood test before starting the trial.
• If you are a woman who could become pregnant, you must either not be sexually active, have a partner who has had a vasectomy, or be using two reliable forms of contraception.
• If you are a woman, you agree not to donate or freeze eggs for the duration of the study and for 6 months after your last dose of treatment.
• If you are a man, you agree to use a condom during any sexual activity where ejaculation could occur, throughout the study and for at least 100 days after your last dose of treatment.
• If you are a man, you agree not to donate sperm during the study and for at least 100 days after your last dose of treatment.
• Your blood test results meet specific minimum thresholds for red blood cells, platelets, white blood cells, liver function, kidney function, and bilirubin levels (confirm exact values with trial site).

Who may not be able to join:

• You have a different type of blood or protein disorder such as Waldenström's macroglobulinemia, POEMS syndrome, or primary amyloid light chain amyloidosis.
• There are signs that your multiple myeloma has spread to your brain or spinal fluid.
• You have moderate or severe nerve pain or nerve damage in your hands or feet.
• You have another ongoing blood cancer or bone marrow disorder (other than multiple myeloma).
• You have a history of another cancer that is considered high risk of coming back and may need treatment.
• You have had another active cancer requiring treatment in the last 24 months, with some exceptions for certain early-stage or cured cancers (confirm with trial site).
• You have had a stroke in the 6 months before signing the consent form.
• You have significant heart problems, such as severe heart failure, a recent heart attack or bypass surgery within 6 months, an uncontrolled irregular heartbeat, a history of serious heart rhythm problems, or severe heart muscle disease.
• You have an uncontrolled medical or mental health condition that could interfere with the study, such as uncontrolled diabetes, an active serious infection, certain autoimmune diseases, a digestive condition that affects how you absorb medicines, severe mental health issues, or substance abuse problems.
• You have any other condition that, in your doctor's opinion, would make it unsafe or unsuitable for you to take part.
• You have a known severe allergy or intolerance to any of the medicines used in this trial.
• You have an active hepatitis B or hepatitis C infection.
• You have previously received systemic treatment or a stem cell transplant for any plasma cell disorder, except for a short emergency course of steroids.
• You have had major surgery within 2 weeks before starting treatment, have not fully recovered from surgery, or have major surgery planned during the study period.
• You have a medical reason why you cannot take the combination of drugs used in this trial (confirm with trial site).
• You have recently received certain other investigational drugs, live vaccines, certain antibody therapies, or specific medications that affect how drugs are processed in your body (confirm timelines with trial site).
• You are currently pregnant, breastfeeding, or planning to become pregnant during the study or within 6 months of your last dose.
• You are a man planning to father a child during the study or within 100 days of your last dose.

Important: Always verify eligibility with the trial site directly before applying.