Phase 1 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have a type of T-cell lymphoma (specifically peripheral T-cell lymphoma-NOS, anaplastic large cell lymphoma, or mycosis fungoides) that has come back or stopped responding to previous treatment (this applies to Group E of the trial)
• Your liver enzyme levels (ALT and AST) are within an acceptable range, tested within the last 15 days
• Your kidney function is within an acceptable range, tested within the last 15 days
• Your liver's bilirubin levels are within an acceptable range, tested within the last 15 days
• Your blood clotting tests are within an acceptable range, tested within the last 15 days
• If you have an existing liver condition, it must not be more severe than a certain stage (called "Child Pugh Class A") (confirm with trial site)
• If you could become pregnant, you must have a negative pregnancy test taken within the last 15 days
• Your white blood cell counts, platelet counts, and haemoglobin (red blood cell) levels are at or above the required levels, tested within the last 14 days
• You have at least one measurable area of disease visible on a CT or MRI scan (a spot larger than 2 cm), or a measurable number of tumour cells in your blood, or a skin lesion larger than 2 cm
• The lymphoma has not spread to your brain or spinal cord
• You are able to give written consent to take part
• You are willing to return to Mayo Clinic for follow-up visits
• Your doctors expect you to live for at least 12 weeks or more
• You are well enough to carry out daily activities with little or no restriction (rated 0, 1, or 2 on a standard health scale)
• You are willing to provide blood or tissue samples for research purposes

Who may not be able to join:

• A treatment that could potentially cure your condition is available and you are willing to accept it
• You currently have an infection that is not under control
• You have active tuberculosis, active hepatitis, or ongoing (chronic) hepatitis
• You have received certain chemotherapy drugs within the last 2 weeks before registering for the trial
• You have received immunotherapy (such as monoclonal antibody treatments) within the last 4 weeks before registering
• You have received an experimental treatment within a specific recent time period before registering (confirm with trial site)
• You have significant heart problems, including serious heart failure, known or suspected coronary artery disease, or certain heart rhythm problems such as atrial fibrillation
• You have an active brain or nervous system disorder, seizure disorder, or known disease affecting the brain or nervous system
• You have tested positive for HIV, or have another condition or are taking medication that weakens your immune system
• You are currently receiving other chemotherapy, immunotherapy, radiation therapy, or any other experimental treatment (note: certain skin care products to manage itching or prevent infection may be allowed for T-cell lymphoma patients, but no topical chemotherapy is permitted)
• You are pregnant, breastfeeding, or are of childbearing potential and unwilling to use effective contraception during the trial and for a period after
• You are a man unwilling to use a condom during sex while on the treatment and for 4 weeks after stopping, even if you have had a vasectomy
• For Group E only: You have been diagnosed with acute myeloid leukaemia (AML) or a specific type of T-cell lymphoma called Angioimmunoblastic T-cell Lymphoma (AITL)

Important: Always verify eligibility with the trial site directly before applying.