Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to give their consent to participate.
• People aged 16 to 19 years old.
• People who can speak and read English.
• People whose main diagnosis is a major depressive episode without psychotic features, confirmed by a structured clinical interview called the MINI-KID.
• People whose depressive symptoms have not improved after trying at least one antidepressant at an adequate dose during the current depressive episode.
• People with at least moderate depressive symptoms, as measured by a score of 40 or higher on a standard depression rating scale (CDRS-R).
• People who are able to follow the treatment schedule required by the trial.
• People who have been on a stable medication and/or therapy plan for at least four weeks before joining the trial.

Who may not be able to join:

• People who have a diagnosis of bipolar I or II disorder.
• People who have had a moderate to severe problem with substance use or alcohol in the past three months (mild cannabis or alcohol use may be allowed — confirm with trial site).
• People whose urine test confirms current use of illegal substances or cannabis.
• People who have an unstable serious medical or neurological condition that is not well controlled (for example, uncontrolled diabetes or kidney problems).
• People whose depression appears to have a physical cause, such as a thyroid problem, that has not been ruled out by a doctor.
• People who are experiencing acute thoughts of suicide or whose life is at risk due to self-neglect.
• People who are pregnant, breastfeeding, or planning to become pregnant during the treatment period (a urine test will be used to check for pregnancy).
• People who have a medical reason why they cannot safely have TMS (a brain stimulation treatment) or an MRI scan — for example, a history of epilepsy or seizures, metal implants in the head, or a pacemaker.
• People who are unwilling to continue their current antidepressant medication during the trial.
• People who are taking more than 1 mg per day of lorazepam or an equivalent medication.
• People who have any other condition that, in the investigators' opinion, would affect their ability to complete the study.

Important: Always verify eligibility with the trial site directly before applying.