Atrial Fibrillation Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with persistent or long-standing persistent atrial fibrillation (an irregular heart rhythm that doesn't stop on its own) — (confirm with trial site which phase applies to you)
• You have persistent atrial fibrillation and have never had a catheter ablation procedure for it before (for one specific phase of the trial)
• You are between 18 and 80 years old
• You have symptoms related to your atrial fibrillation and your doctor has already recommended a standard ablation procedure to treat it
• You are able to sign a consent form agreeing to take part
• You are able and willing to attend all required study visits and complete all study procedures

Who may not be able to join:

• You had a heart attack in the last 3 months
• You had any heart procedure or surgery (including heart ablation or a procedure on your arteries) in the last 3 months
• A blood clot was found in your body on a scan in the last 3 months
• You had open heart surgery (including bypass surgery) in the last 6 months
• You had a stroke in the last 6 months
• You have been told you have the most severe level of heart failure (classified as NYHA Class IV)
• Your heart's pumping ability is very low (less than 30% efficiency)
• The upper left chamber of your heart is larger than 55mm (confirm with trial site which phase this applies to)
• You have had a procedure on the arteries in your neck (stenting or endarterectomy)
• You have had a procedure to close a hole in your heart or seal off part of your heart
• You have a permanent pacemaker, defibrillator, or similar implanted heart device (a small implanted heart monitor called a loop recorder is allowed)
• There is a blood clot, tumour, or other blockage inside your heart or blood vessels that would make the procedure unsafe
• You have unstable chest pain (unstable angina)
• You have had surgery or a repair on your mitral or tricuspid heart valves, or have an artificial heart valve
• You have moderate to severe narrowing of the mitral valve or another serious valve problem
• You have any condition that affects your blood's ability to clot or stop bleeding
• You cannot safely take blood-thinning medication
• Your atrial fibrillation is caused by something temporary or treatable, such as an electrolyte imbalance, recent heavy alcohol use, or another non-heart-related cause
• Your Body Mass Index (BMI) is over 40 (a measure of body weight relative to height)
• You have a serious lung disease, high blood pressure in the lungs, or any ongoing breathing condition
• Your kidneys have failed and you require dialysis or a kidney transplant
• You have a current acute illness, active infection, or blood poisoning (sepsis)
• You have an active dependency on alcohol or drugs
• You have a specific type of thickened heart muscle disease (hypertrophic cardiomyopathy) or a protein build-up condition affecting the heart (cardiac amyloidosis)
• You have heart failure caused by a lung condition (cor pulmonale)
• There is any other reason that might make the procedure take significantly longer than expected (confirm with trial site)
• You are currently pregnant, breastfeeding, or could become pregnant and are not using a reliable method of contraception or abstinence
• You are considered to be part of a vulnerable group (confirm with trial site)
• You are not expected to live for more than one year
• You work for the hospital running the trial or for the company sponsoring it
• You are currently taking part in another study that could interfere with this one

Important: Always verify eligibility with the trial site directly before applying.