Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 16 and 90 years old
• You have been diagnosed with cancer (primary, returned, or spread to other parts of the body) confirmed by a tissue test
• Your doctors expect you to live for more than 3 months
• You are reasonably active and able to care for yourself (confirm with trial site for exact fitness level required)
• Standard cancer treatments have not worked for you, or no standard treatments are available for your cancer
• You have a tumor area that can be biopsied or surgically removed, or fluid in your body containing cancer cells that can be used to collect immune cells
• You have at least one tumor that can be measured during the trial
• Your blood test results (taken within 7 days before joining) show your white blood cells, infection-fighting cells, clotting, kidney function, and liver function are all within acceptable ranges (confirm specific values with trial site)
• There are no medical reasons preventing you from having a biopsy or minor surgery
• If you are able to become pregnant, you must be willing to use reliable contraception from the time you join until one year after treatment ends
• Any previous cancer treatments (including radiation, chemotherapy, or biological therapies) must have stopped at least 28 days before immune cells are collected
• You are able to understand and sign a consent form
• You are able to attend follow-up appointments and follow the study requirements

Who may not be able to join:

• You need regular steroid medications (such as prednisone) at doses above a certain level, or you have an autoimmune disease requiring immune-suppressing treatment
• You have significant breathing or lung problems (confirm with trial site)
• You have serious heart problems, such as severe heart failure, very low blood pressure, uncontrolled chest pain, a weak pumping heart, or serious irregular heart rhythms
• You have HIV, active Hepatitis B or C, syphilis, or certain other infections
• You have a serious physical or mental health condition
• You currently have an active infection throughout your body that requires treatment
• You have received other treatments or medicines within the past month or are currently receiving them
• You have a known allergy to substances similar to those used in cell-based therapies
• You previously received immunotherapy and had a severe side effect (Grade 3 or higher)
• You still have significant side effects from a previous cancer treatment that have not resolved
• You are currently pregnant or breastfeeding
• You have previously had an organ transplant, a stem cell transplant from a donor, or kidney dialysis
• The research team has identified another serious health condition or other reason that makes participation unsuitable

Important: Always verify eligibility with the trial site directly before applying.