Phase 2 Pancreatic Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to participate and have signed a consent form agreeing to take part in the study
• People aged 18 to 75 years old (male or female)
• People who have been diagnosed with pancreatic cancer that has spread to the liver, confirmed by a tissue sample (biopsy), and who have not yet received any systemic cancer treatment
• People who do not have cancer that has spread to the brain or central nervous system
• People who have not received any additional cancer treatment (such as chemotherapy after surgery) in the 6 months before joining the trial
• People with a general health score of 0 or 1 on a standard scale used by doctors to measure how well a person can carry out daily activities (called ECOG performance status)
• People whose doctors estimate they are likely to live for at least 12 weeks
• People whose blood test results show that their major organs (blood, liver, kidneys, and clotting system) are working well enough to meet specific thresholds set by the trial (confirm with trial site for exact values)
• Women who could become pregnant must have a negative pregnancy test within 7 days before joining, and must agree to use reliable contraception during the study and for 8 weeks after the last dose; men must either have had a surgical procedure to prevent fathering children or must agree to use reliable contraception during the study and for 8 weeks after the last dose
• People who are expected to follow the study schedule reliably, including attending follow-up visits as required

Who may not be able to join:

• People who have had another active cancer in the past 5 years, or who currently have another cancer alongside pancreatic cancer
• People with significant heart problems, such as moderate-to-severe heart failure, unstable chest pain (angina), a heart attack within the past year, certain serious heart rhythm problems, or an abnormal electrical reading of the heart (QTc interval) above set limits
• People with high blood pressure that cannot be controlled with medication, where blood pressure remains at or above 140/90 mmHg
• People with abnormal blood clotting results or a tendency to bleed
• People who are currently experiencing active bleeding
• People with an active infection that cannot be controlled, a long-term infectious disease, or a condition that weakens the immune system
• People with known active hepatitis B infection (based on specific blood test results)
• People with an active autoimmune disease, or a history of autoimmune disease that may come back
• People with a known history of severe allergic reactions to any of the study drugs
• People with an uncontrolled infection at the time of screening
• People whose treating doctor considers them unsuitable for the trial for any other medical reason

Important: Always verify eligibility with the trial site directly before applying.