Phase 2 Pancreatic Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years old or older.
• You must have been diagnosed with a specific type of pancreatic cancer (carcinoma, adenocarcinoma, or ductal adenocarcinoma) that is either locally advanced, resectable (able to be removed by surgery), or borderline resectable — confirmed by a lab test on a tissue sample (this can be done during surgery if needed, and a biopsy before surgery is not required).
• If you have previously received chemotherapy, you may still be eligible as long as your cancer did not continue to grow or spread during that treatment.
• Your cancer must be visible and measurable on at least one type of medical scan, such as an MRI, CT scan, PET scan, or ultrasound.
• Your tumour(s) must be suitable for a specific type of surgery called a pancreatoduodenectomy (removal of part of the pancreas and nearby structures).
• Your kidneys must be working well enough, based on blood test results meeting specific levels (confirm with trial site).
• Your blood counts (red blood cells, platelets, and white blood cells) and heart function must meet certain minimum levels, which may be supported by a blood transfusion if needed (confirm with trial site).
• Your liver must be functioning well enough, based on specific blood test results, and your bilirubin level must generally be at or below a certain threshold — a drainage procedure may be done beforehand if needed (confirm with trial site).
• Any serious side effects from previous cancer treatments must have fully resolved before joining the trial.
• If you received chemotherapy before surgery (neoadjuvant chemotherapy) for borderline or locally advanced disease, it must have been completed at least 4 weeks before your planned surgery.
• You must be in good enough general health to carry out daily activities, rated as 0 or 1 on a standard fitness scale used by doctors (confirm with trial site).
• If you are a woman who could become pregnant, you must have a negative pregnancy test at the start of the screening process.
• If you or your partner could become pregnant, you must be willing to use reliable contraception throughout the study and for 6 months after surgery.
• You (or your legal guardian) must sign a written consent form before any study procedures begin.

Who may not be able to join:

• You have been diagnosed with another cancer in the past 2 years.
• After surgery, visible cancer remains in the body (known as an R2 resection).
• You have a specific inherited genetic variation (homozygous UGT1A1) that is known to increase the risk of serious side effects from certain chemotherapy drugs used in this trial (confirm with trial site).
• You currently have an active bacterial, viral, or fungal infection.
• You have a known history of HIV, hepatitis B, hepatitis C, or chronic liver disease.
• It would not be possible to ensure you attend the required follow-up appointments during the study.
• In the opinion of the trial doctors, you may not be able to follow the safety monitoring requirements of the study.
• You are unable to have a CT scan for any reason.
• You have had major surgery within the 14 days before starting the study treatment, or you are still recovering from surgical complications — note that a tumour biopsy or insertion of a central line does not count as major surgery.
• You have other significant illnesses that the trial team considers relevant (confirm with trial site).
• You have previously had an allogeneic stem cell transplant (a transplant using stem cells from a donor).
• You have a serious condition affecting a major organ that could affect your ability to tolerate the treatment (confirm with trial site).
• You are currently pregnant or breastfeeding — if you are breastfeeding, you would need to stop before joining.

Important: Always verify eligibility with the trial site directly before applying.