Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to give written consent to take part in the study.
• You are a man or woman between 18 and 75 years old.
• You have been diagnosed with colorectal cancer (a type of bowel cancer) that has spread to other parts of the body, confirmed by a tissue or cell sample.
• You have already tried one previous treatment for your cancer that did not work.
• You are generally able to carry out daily activities with little or no limitation (confirm with trial site regarding how this is assessed).
• Doctors expect you to live for at least 3 more months.
• You have at least one area of cancer that can be measured on a scan, and that area has not been treated with radiotherapy (or if it has, there is clear evidence the cancer has grown back there).
• Your blood counts, liver, kidney, and other organ functions meet certain minimum levels based on recent blood tests (confirm specific values with trial site).
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 3 days before starting the trial, and you must use effective contraception during the trial and for at least 3 months after your last dose.
• If you are a man whose partner could become pregnant, you must use effective contraception during the trial and for at least 3 months after your last dose.

Who may not be able to join:

• You have had radiotherapy in the 4 weeks before starting the trial and have not yet recovered from its side effects (although radiotherapy to a limited area such as bone more than 4 weeks ago may be acceptable if you have recovered).
• You have active cancer that has spread to the brain or the lining around the brain; people with previously treated and stable brain metastases who have not needed steroid treatment for at least 28 days may be considered, but cancer affecting the lining of the brain excludes you regardless.
• You have had major surgery, an open biopsy, or a serious injury in the 28 days before starting the trial.
• You have a known allergy or sensitivity to fluorouracil or irinotecan (common chemotherapy drugs).
• Your blood pressure is not well controlled with medication (specifically if your readings remain at or above 140/90 mmHg).
• You have significant heart problems, such as moderate-to-severe heart failure, unstable chest pain (angina), a heart attack within the past year, or a serious irregular heartbeat that is not controlled.
• You have had significant bleeding or a clear tendency to bleed in the 3 months before starting the trial, such as stomach or bowel bleeding or bleeding ulcers.
• You have had a blood clot in an artery or vein (such as a stroke, mini-stroke, brain bleed, deep vein clot, or a clot on the lung) in the 6 months before starting the trial.
• You have another cancer that is growing or needs intensive treatment, except for certain skin cancers or early-stage cervical cancer that has already been treated.
• You are currently pregnant or breastfeeding.
• You have other serious health, mental health, or personal circumstances that the doctor believes could put you at risk or affect the quality of the trial (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.