Phase 2 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You fully understand the study and are willing to sign a consent form agreeing to take part
• You are 18 years of age or older
• You have been confirmed by a lab test (tissue or cell sample) to have peritoneal mesothelioma (a cancer affecting the lining of the abdomen)
• You are generally able to care for yourself and are up and about for most of the day (a standard doctor's rating of your daily functioning, scored 0 or 1)
• Your doctors expect you to live for at least 3 more months
• Your blood, liver, and kidney test results meet certain healthy levels (no blood transfusions or certain growth-boosting injections allowed in the 14 days before joining)
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before joining and agree to use reliable contraception during the trial and for 8 weeks after the last dose; if you are a man, you must either have had a sterilisation procedure or agree to use reliable contraception during the trial and for 8 weeks after the last dose
• You have not taken part in any other clinical trial in the 4 weeks before joining, and will not do so during this study

Who may not be able to join:

• You are unable or unwilling to follow the study rules and schedule
• You have received a live vaccine within 4 weeks before joining, or are expected to need one during the study
• You have had another type of cancer in the past 5 years, unless it was a fully cured skin cancer (certain types), a specific type of thyroid cancer, or early-stage cervical cancer that has been treated
• You currently have, or have recently had (within 4 weeks), an active autoimmune disease (a condition where the immune system attacks the body)
• You have previously received a bone marrow or organ transplant from another person
• You have had a serious heart condition such as unstable chest pain or a heart attack within the past 6 months
• You are allergic to the study drugs or any of their ingredients
• Your blood clotting test results are above certain levels (confirm with trial site)
• You have significant abnormalities in your blood salt/mineral levels, as judged by the doctor
• You have uncontrolled high blood pressure before joining (top number 140 or higher and/or bottom number 90 or higher)
• You have had significant bleeding episodes, coughing up blood, or a blood clot, stroke, or mini-stroke within the past 3 to 12 months (timeframes vary by event — confirm with trial site)
• You have significant heart problems, including a recent heart attack, severe chest pain, recent bypass surgery, moderate-to-severe heart failure, certain irregular heart rhythms needing medication, or a weakened heart pump (confirm with trial site)
• You have a serious active infection that is not under control
• You are known to have HIV, or you have active hepatitis B or C infection confirmed by specific blood tests
• You have any other serious illness, abnormal test results, or health condition that the doctor believes makes this trial unsuitable or risky for you
• Your urine test shows a high level of protein, also confirmed by a 24-hour urine collection test
• You need long-term treatment with immune-suppressing drugs or higher-dose steroid medications
• The trial doctor has determined for any other reason that this trial is not appropriate for you

Important: Always verify eligibility with the trial site directly before applying.