Phase 3 Myeloma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You have been diagnosed with multiple myeloma (MM) that has come back after previous treatment
• You have received between 1 and 3 previous treatment plans for multiple myeloma (where each plan included at least 2 cycles of treatment)
• You are eligible to receive one of two specific drug combinations: either isatuximab + pomalidomide + dexamethasone, or isatuximab + carfilzomib + dexamethasone
• Your previous treatment worked at least partially (meaning your myeloma responded to it)
• You are reasonably active and able to care for yourself, with only mild limitations on daily activities (confirm with trial site)
• Any side effects from your previous treatments have either gone away or have stabilised
• You are willing and able to sign a consent form agreeing to take part

Who may not be able to join:

• You have a known allergy or medical reason why you cannot take the study medicines
• Your myeloma has stopped responding to, or you could not tolerate, a type of drug called an anti-CD38 antibody
• You have previously been treated with the specific drug combinations used in this trial (pomalidomide-based or carfilzomib-based combinations as described above)
• You have previously had a donor stem cell transplant (from another person)
• You are planning to have a stem cell transplant before your disease gets worse
• You have been diagnosed with another cancer in the past 3 years (some exceptions may apply, such as certain minor skin cancers — confirm with trial site)
• Your multiple myeloma has spread to the fluid around the brain or spinal cord
• You have a related but different blood condition, such as plasma cell leukaemia, Waldenström's macroglobulinemia, POEMS syndrome, or amyloidosis
• You have another serious medical condition or active infection that could interfere with the trial
• You have uncontrolled chronic lung disease (COPD)
• You have a significant heart condition
• You have an active hepatitis B infection confirmed by a specific blood test
• You are HIV positive or have hepatitis C
• You are currently breastfeeding
• You are already taking part in another clinical trial involving a treatment
• You are unable to give written consent to take part

Important: Always verify eligibility with the trial site directly before applying.