Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with locally advanced rectal cancer (tumours that have grown through the bowel wall or spread to nearby lymph nodes) where the treatment team has decided to use a full course of treatment before surgery.
• People who have not previously received chemotherapy drugs for this rectal cancer.
• People aged 18 years or older.
• People who are reasonably active and able to care for themselves, with a functional ability score within the acceptable range for this trial (confirm with trial site).
• People whose blood counts and organ function (including liver and kidneys) meet the minimum levels required by the trial.
• People with a history of hepatitis B who have an undetectable level of the virus while on suppressive treatment, if that treatment is needed.
• People with a history of hepatitis C who have been successfully treated and cured, or who are currently being treated and have an undetectable level of the virus.
• People who have, or have had, another type of cancer, as long as that cancer or its treatment is unlikely to interfere with this trial's safety or results.
• People with a history of heart disease or prior treatment with heart-affecting drugs, provided a doctor has assessed their heart function and it falls within the acceptable range for this trial.
• People who are able to use an approved form of contraception throughout the trial and for the required period afterwards, as some drugs used in this trial may harm a developing baby.
• People who are willing and able to read and sign a consent form agreeing to participate.
• Both English-speaking and non-English-speaking people are eligible to participate.
• People living with HIV who are on effective treatment and have had an undetectable viral load within the past 6 months.

Who may not be able to join:

• People who have received chemotherapy or radiotherapy within the past year before entering the trial.
• People who are currently taking part in another clinical trial involving an investigational treatment.
• People whose cancer has spread to the brain or to other areas of the body in a way that cannot be surgically removed, meaning standard surgery would not be planned.
• People who have had a serious allergic reaction to metronidazole or similar drugs, or to other medicines used in this trial.
• People with a known history of hypersensitivity to metronidazole or related drugs in the same drug family.
• People currently being treated with the drug disulfiram.
• People with a condition called Cockayne syndrome.
• People with a serious illness that is not currently under control (confirm specific details with trial site).
• People with a mental health condition or personal circumstances that would make it difficult to follow the trial's requirements.
• People who are currently pregnant, as one of the trial drugs may harm an unborn baby.
• People who are currently breastfeeding, as the trial drug may affect nursing infants.
• People who have received chemotherapy drugs within the past year, due to the known effects of chemotherapy on the environment inside tumours.

Important: Always verify eligibility with the trial site directly before applying.