Depression and Anxiety Trial, Recruiting NCT06576076 Sponsor: Massachusetts General Hospital Condition: Depression and Anxiety
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Depression and Anxiety Trial, Recruiting

NCT06576076
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 12 to 18 years old
  • People who currently use cannabis every day or nearly every day (at least 4 days per week on average)
  • People who score 5 or higher on a standard depression questionnaire called the PHQ-9
  • People who have access to a smartphone connected to the internet (iPhone or Android)
  • People who can provide at least one contact person (such as a family member or friend) who can be reached if there are any safety concerns
  • People who provide their own agreement to take part, plus a parent or guardian's agreement if they are under 18 years old
  • People who respond to more than half of the app-based check-in prompts during an initial monitoring phase
  • People who are not planning to stop using cannabis in the next 3 months
  • People whose urine test confirms cannabis use at the start of the study

Who may not be able to join:

  • People who have any condition that would prevent them from fully understanding or participating in the study, including being intoxicated at the time of sign-up
  • People who use cannabis more than 4 times per day on average
  • People who are not able to speak and write English fluently
  • People with significant difficulties in thinking or understanding, for example due to active psychosis, intellectual disability, developmental delay, or a condition affecting brain function
  • People who currently have a diagnosis of epilepsy
  • People who are under the legal care of the government or state (wards of the state)
  • People who answer incorrectly on a knowledge check about how quickly the study team responds to safety concerns raised through the app
  • People who are unable to wear a Fitbit device

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 6 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Randi M Schuster, PhD, Massachusetts General Hospital

Phone: 617-643-6673

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
18 February 2025
Est. completion
30 April 2029

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Aim 1: Cannabis use in the last hour; Aim 1: Motivation to use cannabis to improve mood collected; Aim 2: Depleted mood; Aim 2: Negative cognitive impact; Aim 2: Negative activation; Aim 2: Passive suicidal ideation; Aim 2: Suicidal urges; Aim 2: Non-suicidal self-injury urges

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 6 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov