Phase 2 Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who identify as Latinx and speak Spanish
- Adults between 18 and 64 years old
- People who have been assessed by a study clinician and meet the clinical diagnostic criteria for major depressive disorder
- People whose depression symptom score on a standard rating scale (called the MADRS) is 20 or above at the start of the study
- People who already have both a psychiatrist and a primary care doctor within the MGB (Mass General Brigham) health system
Who may not be able to join:
- People with a history of a primary psychotic disorder
- People with a history of Bipolar I disorder
- People with unstable complex PTSD, as assessed by a study clinician
- People with a history of dissociative identity disorder
- People with a history of a neurocognitive disorder (such as dementia)
- People with a history of severe or recent substance use disorder, as assessed by a study clinician
- People with uncontrolled high blood pressure, a fast heart rate, or unstable heart or lung disease — blood pressure must be below 140/90 mmHg at the initial screening
- People with a history of aortic dissection (a serious condition affecting the main artery from the heart)
- People with a history of heart attack
- People with a history of an aneurysm (a bulge in a blood vessel)
- People with a history of liver impairment
- People with a history of epilepsy
- People with a history of a previous allergic reaction to ketamine
- People with a Body Mass Index (BMI) greater than 35
- People with a Body Mass Index (BMI) less than 18.5
- People who are pregnant, breastfeeding, or planning to become pregnant within 12 weeks of finishing treatment
- People currently enrolled in another clinical trial for depression or another behavioural health condition
- People who are unable to provide informed consent
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Juliana Zambrano, MD, Massachusetts General Hospital
Phone: 617-726-2000
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Evaluate feasibility of a culturally adapted group-based ketamine intervention for Spanish- speaking adults with depression in a community setting; To assess the safety of a ketamine-assisted group psychotherapy intervention for Spanish-speaking participants with depression in a community setting.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.