Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have not taken most types of prescription medications (such as heart medications, anti-seizure medications, antipsychotics, insulin, chemotherapy, or immunosuppressants) in the past 14 days
• People who take certain medications (such as short-acting benzodiazepines, asthma inhalers, steroids, or medical marijuana) fewer than 7 out of the past 14 days may still be considered
• People who take longer-acting benzodiazepines or sleep medications, as long as those medications were not taken within 48 hours of the brain scan
• People who take no more than two non-insulin diabetes medications on a regular basis
• People who stopped taking a disallowed medication at least one month ago and meet all other criteria

Who may not be able to join:

• People who have had 35 or more alcoholic drinks in the past 7 days, or who have had 6 or more drinks on 3 or more separate occasions in the past 7 days
• People who have used illegal drugs on 7 or more days in the past 2 weeks
• People with epilepsy or a history of seizures
• People with a history of heart attack, stroke, bypass surgery, angioplasty, heart failure, or irregular heart rhythm
• People with very high blood pressure (above 160 systolic and/or above 100 diastolic)
• People who have received cancer treatment in the past 12 months (except for non-melanoma skin cancer)
• People with liver disease or kidney disease
• People with Type 1 diabetes
• People with a history of a major neurological condition or brain injury that still causes ongoing symptoms or thinking difficulties (such as multiple sclerosis, cerebral palsy, or a serious head injury)
• People with a history of schizophrenia or bipolar disorder
• People with a lung disease that requires ongoing drug treatment (though occasional use of asthma or allergy inhalers is not automatically disqualifying)
• People who are pregnant or planning to become pregnant in the next 3 months
• People with a visual impairment that would prevent them from reading printed or on-screen text
• People with colour blindness that may affect their ability to distinguish colours on study tasks
• People who are not comfortable in confined spaces and would not be comfortable in an MRI scanner (a mock MRI trial run may be offered to help people decide)
• People who have non-removable metal implants, devices, or objects in or on the body that are not compatible with MRI (compatibility of medical devices may be assessed with documentation from a medical professional)
• People who are taller than 7 feet 2 inches or weigh more than 350 pounds, as they may not fit in the MRI scanner
• People who frequently work night shifts (where half or more of a full workday falls between midnight and 8am, occurring more than 12 times in the past year)
• People who have undergone brain stimulation procedures (such as TMS, tDCS, vagus nerve stimulation, or transcranial ultrasound) as part of research or treatment in the past month
• People with a lifetime history of a suicide attempt, or who have experienced suicidal thoughts within the past year

Important: Always verify eligibility with the trial site directly before applying.