Phase 2 Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are seen as an outpatient (not currently staying in a hospital) and are able to give your own consent to participate
• You are at least 60 years old
• You have been diagnosed with major depressive disorder based on a structured psychiatric interview
• Your depression has been assessed as moderate to severe using a standard rating scale (a score of 15 or higher on the MADRS)
• You have been on a stable dose of any psychiatric medications, including antidepressants, for at least 4 weeks
• You are able to follow the study schedule and attend appointments as required

Who may not be able to join:

• You have been diagnosed with a major neurocognitive disorder (such as dementia)
• You are currently experiencing psychosis (such as hallucinations or delusions)
• You have an unstable or poorly controlled medical condition affecting your heart, hormones, blood, liver, lungs (including asthma), or kidneys
• You have been diagnosed with a specific type of eye condition called narrow angle glaucoma
• You have unexplained skin lesions that have not been checked, or you have a history of melanoma (a type of skin cancer)
• You have had a heart attack at any point in the past
• You have a heart rhythm problem affecting the upper or lower chambers of your heart
• You have a history of seizures or a seizure disorder (such as epilepsy)
• You have a history of peptic ulcer disease (stomach or intestinal ulcers)
• You have had an allergic or sensitivity reaction to levodopa, carbidopa, or any ingredient in the study medication (Levocarb)
• You are currently having thoughts of suicide
• Your psychiatric medication was started or the dose was changed less than 4 weeks before joining the trial
• You regularly take medications that block dopamine, or regularly use sedative medications (benzodiazepines) at a dose of 2mg lorazepam equivalent or more per day
• You are unable to complete memory and thinking tests conducted in the English language
• You have a significant problem with your hearing or vision that cannot be corrected well enough to complete the thinking and memory tests
• You have been falling frequently, with one or more falls per week over the past 4 weeks

Important: Always verify eligibility with the trial site directly before applying.