Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with Familial Adenomatous Polyposis (FAP) — either confirmed by a genetic test showing an APC gene mutation, or by a clinical diagnosis involving more than 50 growths (polyps) in the large bowel
• People who still have their rectum (the lower part of the large bowel) intact — either before bowel surgery or after bowel surgery where the rectum was kept
• People who have at least 5 rectal polyps larger than 2 mm, confirmed by a recent camera examination of the lower bowel
• People who have had no sign of invasive cancer for at least 6 months before screening, and who are at least 6 months past any cancer treatment (such as surgery, chemotherapy, immunotherapy, hormone therapy, or radiation)
• People who have not started daily use of anti-inflammatory medications (such as sulindac or celecoxib) within 3 months before the study starts, and who do not use them frequently during the study
• People who have not started weight-loss medications (such as semaglutide, liraglutide, tirzepatide, or orlistat) within 3 months before the study starts, and who do not use them during the study
• Adults aged 18 years or older
• People living with HIV who are on effective treatment and have had an undetectable level of the virus in the last 6 months
• People with a history of chronic hepatitis B infection whose virus levels are undetectable while on appropriate treatment
• People with a history of hepatitis C who have been treated and cleared of the infection, or who are currently on treatment with an undetectable virus level
• People on long-term antiviral medication for herpes simplex virus (HSV)
• Women who could become pregnant and who agree to use reliable contraception (such as hormonal methods, barrier methods, or abstinence) for the full duration of the study and until the final endoscopy is completed — and who agree to inform the study team immediately if pregnancy occurs or is suspected
• People who are currently inactive, defined as doing 60 minutes or less of moderate or vigorous exercise per week over the past month (as measured by a standard questionnaire)
• People who have no known reasons preventing them from starting a regular exercise program (as assessed by a standard health questionnaire called the PAR-Q+)
• People who have enough space in their home to fit a treadmill for the study period, or who already have access to a suitable treadmill (for example, through a gym membership) approved by the study's exercise specialist
• People whose home can have exercise equipment delivered and set up by the study team (this does not apply if an outside treadmill is being used)
• People with internet or Wi-Fi access at home (those without internet may be provided with a pre-paid tablet device)
• People who are willing and able to attend scheduled visits, follow treatment plans, and complete all required study activities
• People who have received approval from their doctor to participate
• People who are able to understand the study and are willing to sign a written consent form

Who may not be able to join:

• People who have had their entire rectum and colon surgically removed (total proctocolectomy)
• People whose biopsy at screening shows high-grade abnormal cell changes or cancer
• People who have had radiation treatment to the pelvic area
• People currently taking part in another clinical trial involving an experimental treatment
• People with serious uncontrolled medical conditions, including severe heart failure, unstable chest pain, irregular heart rhythms, or mental health or personal circumstances that would make it difficult to follow the study requirements
• People with severe, ongoing, or poorly controlled conditions affecting the kidneys, urinary system, liver, blood, hormones, heart, blood vessels, lungs, joints, nerves, mental health, or metabolism
• People who are pregnant, as camera examinations of the bowel are not recommended during pregnancy

Important: Always verify eligibility with the trial site directly before applying.