Phase 1 Myeloma Trial, Recruiting NCT06644118 Sponsor: Zhejiang University Condition: Myeloma
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Phase 1 Myeloma Trial, Recruiting

NCT06644118
Recruiting Phase 1

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been officially diagnosed with multiple myeloma based on recognised diagnostic standards
  • Your multiple myeloma has come back or stopped responding to treatment, and you have already tried at least 3 different types of myeloma treatment (including one from each of three specific drug groups: a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody)
  • Your disease has continued to grow within 12 months of your last treatment, or within the past 6 months and did not respond to your most recent treatment
  • Tests show there is a measurable amount of myeloma in your body (through blood, urine, or light chain tests)
  • Your myeloma cells carry certain proteins on their surface (called BCMA or GPRC5D); if you have previously had treatment targeting BCMA, your cells must show the GPRC5D protein
  • You are generally able to carry out daily activities with no more than minor limitations (confirm with trial site)
  • Your doctors expect you to live for at least 12 more weeks
  • Your blood counts and organ function meet certain minimum levels, including your red blood cells, platelets, white blood cells, liver function, kidney function, calcium levels, oxygen levels, and heart function (confirm specific values with trial site)

Who may not be able to join:

  • You have a single isolated tumour made of myeloma cells (called a solitary plasmacytoma) rather than widespread myeloma
  • Your myeloma has spread to your brain or spinal cord, or you are showing signs that it might have
  • You have previously had a stem cell transplant using cells from another person, or you had a stem cell transplant using your own cells within the last 12 weeks
  • You currently have another active cancer (some exceptions may apply, such as certain cured skin cancers or early-stage cancers that are not spreading — confirm with trial site)
  • You have another serious medical condition that your doctor feels could make it unsafe for you to take part in the trial
  • You have been diagnosed with a related but different blood condition, such as plasma cell leukaemia, Waldenström's macroglobulinaemia, POEMS syndrome, or primary AL amyloidosis

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: (+86)13605714822

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 1
Sponsor
Zhejiang University
Registry
ClinicalTrials.gov
Start date
23 October 2024
Est. completion
1 October 2027

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Dose-limiting toxicity (DLT); Treatment emergent adverse event (TEAE) incidence and severity

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov