Peripheral Neuropathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have had a traumatic spinal cord injury at or above the T1 level (roughly the upper back or neck), either within the last 6 months (and considered medically stable) or more than 6 months ago, with any level of impairment severity.
• People who have had a peripheral nerve injury (with or without a spinal cord injury) and are either before or after surgery to transfer nerves in the arm or hand — either within 6 months of that surgery (considered medically stable and appropriate to participate by their neurosurgeon) or 6 or more months after surgery.
• People who show at least some response in an arm or hand muscle on the affected side when electrical stimulation is applied to that muscle, confirmed at a baseline assessment.
• People who show at least some detectable voluntary muscle activity in at least one arm or hand muscle on the affected side, confirmed by electrical muscle testing at a baseline assessment.
• For one part of the study only: people who are able to commit to treatment and assessment sessions over a period of up to 4 months.

Who may not be able to join:

• People who have a traumatic brain injury, stroke, multiple sclerosis, or another condition that could affect how the nerves and muscles work.
• People with severe muscle stiffness or spasms that could prevent them from taking part in the study, as assessed by the investigator.
• People with significant difficulties in thinking, memory, or mental health — including dementia, major depression, or other serious medical conditions affecting cognition.
• People for whom electrical skin stimulation would not be safe — for example, those with broken or damaged skin where the electrodes would be placed, blood clots, or a skin disease in the relevant area.
• People with poorly controlled autonomic dysreflexia (a condition involving sudden high blood pressure) that could be triggered by electrical stimulation.
• People with an unhealed bone fracture, joint stiffening, or pressure sore in the arm or hand.
• People who have an implanted nerve stimulation device, such as a deep brain stimulator or vagal nerve stimulator.
• People who have a cardiac pacemaker or electrical lines inside the heart.
• People who require other treatments or care that could interfere with taking part in the study.
• People who are currently taking experimental drugs or other treatments known to affect nerve and muscle function.
• People with substance use disorders, including alcohol or drug dependency.
• People who are pregnant, breastfeeding, or planning to become pregnant during the study period.
• People who the investigators consider unsuitable or unsafe for the study for any other reason.

Important: Always verify eligibility with the trial site directly before applying.