Phase 4 Depression and Anxiety Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 65 years old (both men and women)
• People who have been diagnosed with Major Depressive Disorder (a type of depression) using standard clinical assessment tools
• People who are in generally good health, based on their medical history and a physical check-up at screening
• People whose body temperature, blood pressure, and heart rate fall within specific normal ranges when measured after resting for 3 minutes
• People who weigh between 50 and 100 kg and have a body mass index (a measure of body weight relative to height) between 19 and 26
• People who have adequate vision and hearing to complete thinking and memory tests
• People who are willing and able to read, understand, and sign a consent form before any study procedures begin
• People who are able to communicate clearly with the research team and follow the study requirements
• People who are legally able to give their own consent to take part

Who may not be able to join:

• People with depression who also have a severe or unstable neurological, physical, or other psychiatric condition
• Healthy participants (comparison group) who have any psychiatric, severe neurological, or serious physical health condition
• People who are experiencing symptoms of psychosis (such as hallucinations or delusions)
• People who are currently at acute risk of suicide
• People who have any reason they cannot safely have an MRI or PET scan
• People who have any metal implants in their head
• People with a history of significant drug allergies, or allergic conditions such as asthma, hives, or eczema, or a known allergy to the study medications bupropion or escitalopram
• People with other significant abnormalities found during physical examination, neurological assessment, blood tests, or heart trace (ECG) that, in the investigator's judgement, would prevent participation
• People who have taken antidepressants or other medications affecting mood or mental health in the past 6 months, or who have previously taken escitalopram or bupropion specifically
• People who have previously received certain depression treatments including deep brain stimulation (DBS), electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or ketamine
• People who currently smoke, or who have a problem with alcohol, recreational drugs, or any substance use disorder as defined by clinical criteria
• People who are unwilling or unable to follow the study procedures and instructions
• People with a positive pregnancy test
• People who are known to be pregnant or breastfeeding
• People whose MRI scan shows evidence of stroke, brain injury, or any structural abnormality in the brain
• People with a history of alcohol or drug misuse
• People who have taken part in another clinical trial within the 12 weeks before this study begins
• People whose circulation between two specific arteries in the wrist (radial and ulnar) is found to be incomplete in either hand, based on a simple test (confirm with trial site)
• People who have received significant radiation exposure (above 5 millisieverts) through participation in other research trials in the past 10 years

Important: Always verify eligibility with the trial site directly before applying.