Phase 2 Multiple Sclerosis Trial, Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- You are between 18 and 60 years old (inclusive) at the time of screening
- You are willing and able to sign a consent form before the study begins
- You are able to communicate clearly with the study team and follow all study instructions and procedures
- You are able to have a lumbar puncture (a procedure to collect fluid from your spine), blood draws, and brain and spinal MRI scans
- You have been diagnosed with Secondary Progressive MS (SPMS) or Primary Progressive MS (PPMS) based on specific 2017 diagnostic guidelines
- Your first MS symptoms appeared 15 years ago or less
- You are able to walk to some degree, with a disability score between 3 and 6.5 on a standard MS scale (confirm with trial site)
- Your MS has gotten measurably worse in the last 24 months, based on that same disability scale
- You have had no MS relapses in the last 24 months
- Your most recent MRI showed no signs of active inflammation (no "enhancing lesions") in your brain or spinal cord
- You are up to date on all recommended vaccinations for people with weakened immune systems, at least 6 weeks before a specific treatment step in the trial
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- You have been diagnosed with Relapsing MS or "active" Progressive MS under the same 2017 guidelines
- You have or have had another significant brain or nervous system condition other than MS, such as stroke, brain injury, epilepsy, or seizures
- You have had a significant heart condition — such as a heart attack, severe heart failure, irregular heartbeat, or uncontrolled high blood pressure — within the last 6 months
- You have a history of, or symptoms consistent with, a serious brain infection called Progressive Multifocal Leukoencephalopathy (PML)
- You have a significant active infection, including hepatitis B or hepatitis C, or a chronic or recurring infection confirmed by tests, imaging, or symptoms within one month before a specific collection procedure
- You have donated blood or lost more than 400 mL of blood in the 3 months before screening
- You have previously received a stem cell therapy, organ transplant, or gene therapy
- You have a physical condition or spinal abnormality that would make a lumbar puncture unsafe or too risky for you
- You have a bleeding disorder, blood clotting problem, or abnormal blood vessels near the spine that could make a lumbar puncture dangerous
- You are currently taking blood thinners (such as warfarin) or anti-clotting medications — with the exception of low-dose aspirin (100 mg/day or less) or low-dose ibuprofen (600 mg/day or less)
- You are unwilling or unable to have MRI scans — for example, due to severe claustrophobia, or because you have a pacemaker, defibrillator, metal implants, or metal fragments in your body
- You are pregnant or currently breastfeeding
- You have previously had your spleen surgically removed
- You have active or latent (hidden) tuberculosis (TB), confirmed by a specific blood test or visible on lung imaging such as an X-ray
- You have a significant mental health condition, or a serious lung, kidney, liver, hormone, blood, or digestive disease that the study doctor believes could affect your safety or the study results
- You have had a significant blood clot event in the past 4 weeks, or you have a condition that requires you to regularly take blood-thinning or anti-clotting medication (with the same exceptions noted above)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
2 site(s) in Australia. Confirm current status and contact details directly with the trial site.
Primary endpoints
Number of participants with dose limiting toxicities (DLTs), Adverse Events (AEs), and Serious Adverse Events (SAEs)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 2 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.