NCT06675864

Who might be able to join this trial:

• You are between 18 and 60 years old (inclusive) at the time of screening
• You are willing and able to sign a consent form before the study begins
• You are able to communicate clearly with the study team and follow all study instructions and procedures
• You are able to have a lumbar puncture (a procedure to collect fluid from your spine), blood draws, and brain and spinal MRI scans
• You have been diagnosed with Secondary Progressive MS (SPMS) or Primary Progressive MS (PPMS) based on specific 2017 diagnostic guidelines
• Your first MS symptoms appeared 15 years ago or less
• You are able to walk to some degree, with a disability score between 3 and 6.5 on a standard MS scale (confirm with trial site)
• Your MS has gotten measurably worse in the last 24 months, based on that same disability scale
• You have had no MS relapses in the last 24 months
• Your most recent MRI showed no signs of active inflammation (no "enhancing lesions") in your brain or spinal cord
• You are up to date on all recommended vaccinations for people with weakened immune systems, at least 6 weeks before a specific treatment step in the trial

Who may not be able to join:

• You have been diagnosed with Relapsing MS or "active" Progressive MS under the same 2017 guidelines
• You have or have had another significant brain or nervous system condition other than MS, such as stroke, brain injury, epilepsy, or seizures
• You have had a significant heart condition — such as a heart attack, severe heart failure, irregular heartbeat, or uncontrolled high blood pressure — within the last 6 months
• You have a history of, or symptoms consistent with, a serious brain infection called Progressive Multifocal Leukoencephalopathy (PML)
• You have a significant active infection, including hepatitis B or hepatitis C, or a chronic or recurring infection confirmed by tests, imaging, or symptoms within one month before a specific collection procedure
• You have donated blood or lost more than 400 mL of blood in the 3 months before screening
• You have previously received a stem cell therapy, organ transplant, or gene therapy
• You have a physical condition or spinal abnormality that would make a lumbar puncture unsafe or too risky for you
• You have a bleeding disorder, blood clotting problem, or abnormal blood vessels near the spine that could make a lumbar puncture dangerous
• You are currently taking blood thinners (such as warfarin) or anti-clotting medications — with the exception of low-dose aspirin (100 mg/day or less) or low-dose ibuprofen (600 mg/day or less)
• You are unwilling or unable to have MRI scans — for example, due to severe claustrophobia, or because you have a pacemaker, defibrillator, metal implants, or metal fragments in your body
• You are pregnant or currently breastfeeding
• You have previously had your spleen surgically removed
• You have active or latent (hidden) tuberculosis (TB), confirmed by a specific blood test or visible on lung imaging such as an X-ray
• You have a significant mental health condition, or a serious lung, kidney, liver, hormone, blood, or digestive disease that the study doctor believes could affect your safety or the study results
• You have had a significant blood clot event in the past 4 weeks, or you have a condition that requires you to regularly take blood-thinning or anti-clotting medication (with the same exceptions noted above)

Important: Always verify eligibility with the trial site directly before applying.