Phase 2 Myeloma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with multiple myeloma (confirmed by a tissue test) with symptoms, and you are planning to have a stem cell transplant using your own stem cells, with a specific chemotherapy drug (melphalan) as part of that process, within 12 months of your diagnosis
• You are at least 60 years old
• You have enough stem cells collected and ready to be used (at least 3 million of a specific type called CD34+ cells per kg of body weight)
• You are in reasonably good general health, able to carry out most daily activities (confirm with trial site for exact fitness level required)
• Your lungs are working at more than 45% of expected capacity, based on a breathing test done within the past 6 weeks
• Your heart is pumping at more than 45% efficiency, based on a heart scan done within the past 6 weeks
• Your recent blood test results (within the past 6 weeks) show your platelet count, liver function, and kidney function are all above certain minimum levels (confirm with trial site for exact values)
• If you are a man who is sexually active with a woman who could become pregnant, you must agree to use a barrier form of contraception (such as a condom) during the study and for 3 months after your last dose, and must not donate sperm during this time

Who may not be able to join:

• You have previously been treated with drugs that target a substance called IL-6 or its receptor
• You have had another type of cancer in the past 2 years, with some exceptions for certain treated and inactive skin or cervical cancers (men with prostate cancer being monitored but not treated may be considered — confirm with trial site)
• You have another medical condition (such as an autoimmune disease or active infection) that could interfere with the study or make participation unsafe
• You have had a heart problem requiring treatment in the last 3 months, or you have uncontrolled heart failure or an uncontrolled irregular heartbeat, or your heart's electrical activity reading is outside of a safe range (confirm with trial site)
• You have received a live vaccine within 4 weeks before starting the study
• You have a significant active infection, or are known to have HIV, hepatitis C, or hepatitis B, unless certain conditions are met showing the infection is under control (confirm with trial site for details)
• You have taken part in another clinical trial or used an experimental treatment or device within the past 14 days (or within 5 half-lives of that drug) before joining, or are currently in the treatment phase of another study
• You were hospitalised for an infection or had major surgery requiring general anaesthesia within the 2 weeks before joining, or have not fully recovered from surgery
• You are a man who plans to father a child while on the study or within 3 months after your last dose of the study drug

Important: Always verify eligibility with the trial site directly before applying.