Atrial Fibrillation Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old at the time of joining the trial
• People who are willing and able to give informed consent and attend all required visits, tests, and follow-up appointments
• People diagnosed with paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes) who have had at least one recorded episode in the past year, confirmed by a heart monitoring test such as an ECG or Holter monitor
• People whose atrial fibrillation symptoms continued or who could not tolerate at least one medication used to control heart rhythm or heart rate (such as beta blockers, calcium channel blockers, or certain antiarrhythmic drugs)
• People whose left atrial chamber of the heart measures 5.5 cm or less in width, confirmed by a heart scan within the past 3 months
• People whose heart pumping function is at least 40%, confirmed by a heart scan within the past 12 months
• People who have completed a standard heart health assessment and been considered a suitable candidate for the investigational procedure by the study doctors

Who may not be able to join:

• People who have an implanted electronic heart device, such as a pacemaker, defibrillator, or a device in the left atrial appendage
• People who have an artificial heart valve
• People whose irregular heartbeat is caused by an imbalance in body salts, a thyroid condition, or another reversible or non-heart-related cause
• People whose atrial fibrillation episodes last longer than 7 days
• People who have previously had an ablation procedure for atrial fibrillation
• People who have taken the heart medication amiodarone at any point in the 3 months before joining
• People with a history of pericarditis (inflammation around the heart), or evidence of it on a recent heart scan
• People with a history of rheumatic fever
• People who have previously had a medical procedure involving the left chamber of the heart, such as a prior ablation, closure of a hole in the heart, or a procedure to block the left atrial appendage
• People with a history of serious ongoing digestive problems affecting the food pipe, stomach, or untreated acid reflux
• People with a history of abnormal bleeding or a blood clotting disorder
• People who cannot take blood-thinning medications such as heparin, dabigatran, apixaban, or warfarin
• People with an active cancer or who have been treated for cancer within the past 24 months
• People who have a significant infection or signs of serious illness on the day of the procedure
• People who have had a stroke or mini-stroke (TIA) in the past 6 months, any prior bleeding in the brain, or a permanent neurological condition
• People with advanced heart failure classified as NYHA class IIIb or IV, or who have been hospitalised for heart failure in the past 3 months
• People with a body mass index (a measure of body weight relative to height) greater than 35
• People with significantly reduced kidney function, or who have ever required dialysis
• People with a history of serious untreated low blood pressure, an abnormally slow heart rate, or the heart's inability to increase its rate appropriately
• People who have experienced any of the following within the past 3 months: major surgery, a heart attack, unstable chest pain, a coronary artery procedure, a sudden cardiac arrest event, or a blood clot in the left atrial appendage that has not cleared
• People who have had an organ or blood cell transplant, or who are currently being assessed for one
• People with high blood pressure in the lungs (pulmonary artery pressure above 50 mmHg), severe chronic lung disease, or restrictive lung disease
• People with other significant uncontrolled or unstable medical conditions, such as uncontrolled heart rhythm problems, an overactive thyroid, or a serious clotting disorder
• People with a life expectancy of less than one year
• People with a significant psychological condition that, in the treating doctor's opinion, would prevent them from meeting the study requirements
• Women who are pregnant, breastfeeding, or planning to become pregnant during the study period
• People the investigator considers unsuitable for other reasons, such as uncontrolled substance addiction, a congenital condition, or frailty

Important: Always verify eligibility with the trial site directly before applying.