Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been newly diagnosed with multiple myeloma, have completed at least 4 cycles of initial treatment, and have undergone high-dose chemotherapy followed by a stem cell transplant using their own cells — all within specific timeframes (the transplant within 12 months of starting initial treatment, and joining the trial within 6 months of the transplant).
• People whose myeloma showed at least a partial response (meaning the cancer responded meaningfully to treatment) before starting maintenance therapy.
• People who have a general health and activity level that falls within a certain range, as measured by a standard medical scoring system — roughly meaning they are fully active, have some limitations in strenuous activity, or are able to care for themselves but unable to do much active work (confirm with trial site).
• People who have had additional treatment after their stem cell transplant (known as consolidation therapy) are still permitted to join.
• People whose blood cell counts and platelet levels meet certain minimum thresholds measured by blood tests (confirm with trial site for exact values).
• People who have no active infection at the time of joining.
• People whose liver function tests and kidney function fall within acceptable ranges as measured by blood tests (confirm with trial site for exact values).

Who may not be able to join:

• People whose myeloma did not respond to, or who could not tolerate, the drug lenalidomide — this applies to one of the treatment groups in the trial.
• People whose myeloma did not respond to, or who could not tolerate, either lenalidomide or daratumumab — this applies to another treatment group in the trial.
• People whose multiple myeloma has already progressed (worsened) while on treatment before the screening stage of the trial.
• People who have a chronic lung condition (COPD) where breathing tests show their lung function is below 50% of what would be expected for a healthy person.
• People who have had moderate or severe persistent asthma at any point in the past 2 years, or who currently have asthma that is not well controlled.
• People who have had a stroke or a serious blood clot event within the 12 months before joining the trial.

Important: Always verify eligibility with the trial site directly before applying.