Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been newly diagnosed with pancreatic cancer that has either spread to nearby areas and cannot be removed by surgery (Group 1), or has spread to other parts of the body (Group 2), confirmed by a tissue or cell sample.
• You are able to receive an initial course of chemotherapy (called mFOLFIRINOX, up to 4 cycles) before the main treatment in this trial.
• The tumour can be physically reached for the special radiation seed implant used in this trial.
• You have at least one tumour that can be measured using standard imaging guidelines.
• Your tumour measures 5 cm (about 2 inches) or less at its widest point.
• A team of specialists has agreed that the radiation implant procedure is appropriate for you.
• You are reasonably active and able to care for yourself (confirm with trial site for exact fitness level required).
• Your doctors expect you to live for more than 6 months.
• Your blood cell counts and kidney and liver function are within acceptable ranges (confirmed by blood tests).
• A specific blood clotting measurement is within a safe range (if you are not taking Warfarin).
• You are 18 years of age or older.
• You are willing and able to sign a consent form agreeing to take part.
• If you are a woman who could become pregnant, you must have a negative pregnancy test before the implant and agree to use contraception for at least 3 months after treatment.
• You agree to use contraception (such as a vasectomy or barrier method) before, during, and for 3 months after the implant procedure.

Who may not be able to join:

• For Group 1 only: Your pancreatic cancer is classified as "borderline" for surgery, or you are considered suitable for surgery but have not declined it.
• You have previously received any treatment for pancreatic cancer — such as radiation, immunotherapy, or chemotherapy — other than 1 to 4 cycles of the mFOLFIRINOX chemotherapy mentioned above.
• You have a known allergy or sensitivity to any component of the treatments used in this trial.
• You are currently taking long-term medicines that suppress your immune system (short, occasional use of steroids may be acceptable — confirm with trial site).
• You have significant heart problems, such as severe heart failure, uncontrolled heart disease, irregular heartbeat, uncontrolled high blood pressure, or a heart attack within the past 12 months.
• You have another serious uncontrolled illness, an active infection needing treatment, or a mental health or substance use condition that could affect your ability to take part in the trial.
• You have another cancer that is currently growing or requires active treatment (some early-stage or treated skin cancers, low-risk prostate cancer, or cervical cancer in its earliest stage may be exceptions — confirm with trial site).
• You need a treatment not included in this trial's plan that could interfere with measuring the results.
• You are unwilling or unable to use contraception as required by the trial.
• You have taken part in another interventional clinical trial in the past 30 days that could affect the results of this study.
• The trial team believes you are unlikely to be able to follow the trial's requirements.
• You are breastfeeding, or you are a woman who could become pregnant and are unwilling or unable to use an acceptable form of contraception for 3 months after the implant.
• You have a genetic condition, inflammatory bowel disease, or connective tissue disease that puts you at higher risk of complications from radiation treatment.

Important: Always verify eligibility with the trial site directly before applying.