Phase 1 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to participate and have signed a consent form agreeing to take part
• You are 18 years old or older, any gender
• You have been diagnosed with an advanced solid tumour cancer that has caused a build-up of fluid around the lungs (malignant pleural effusion) confirmed by lab testing, whether the cancer started in the lungs or spread there from elsewhere
• Your cancer has not responded to standard treatments, or no standard treatments are available
• You have not received any medication injected into the chest cavity in the month before joining (routine diagnostic fluid removal is acceptable)
• You are willing to provide tumour tissue or fluid samples, and your cancer cells test positive for a protein called B7-H3
• Your general health and ability to carry out daily activities is rated at a reasonable level (ECOG score of 0, 1, or 2 — confirm with trial site)
• Your recent blood test results meet specific requirements, including: enough white blood cells, platelets, and red blood cells; liver, kidney, and blood clotting function within acceptable ranges (confirm exact values with trial site)
• Any side effects from previous cancer treatments have mostly resolved before starting this trial
• If you are able to have children, you agree to use reliable contraception from consent until 6 months after your last dose

Who may not be able to join:

• You have a known allergy to the study drug or any of its ingredients
• You have a medical reason that prevents chest drainage, or draining the fluid would not help you
• You are already receiving other anti-cancer treatments or anything that could affect the fluid around your lungs (other than diagnostic procedures)
• You have had radiation therapy within the 2 weeks before starting the trial
• You have had major surgery within 4 weeks before starting and have not fully recovered
• You are currently taking steroid medications or other immune-suppressing drugs within 1 week before starting
• You have taken part in another clinical drug trial within the past 4 weeks
• You have previously received a specific type of cell therapy that targets B7-H3 (CAR-T cell therapy)
• You have an active infection, serious blood clotting problems, or other significant ongoing illnesses
• You have severe heart, lung, liver, or kidney disease beyond specified thresholds (confirm details with trial site)
• You have a severe autoimmune disease
• You have previously received a transplant of an organ or tissue from another person
• You received a live vaccine within 2 weeks before starting, or plan to receive one during the study
• You have an active hepatitis B infection, active hepatitis C infection, HIV, or a positive syphilis test
• You have serious problems with memory, thinking, or understanding, as assessed by the study doctor
• You are pregnant or breastfeeding
• You have any other medical or personal circumstances that the study doctor believes would make participation unsuitable

Important: Always verify eligibility with the trial site directly before applying.