Phase 2 Peripheral Neuropathy Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 65 years old
- A pain specialist has diagnosed you with long-lasting nerve pain (chronic neuropathic pain)
- Your nerve pain is rated as moderate to severe based on a standard patient questionnaire
- You have already tried at least two medications recommended in Canadian guidelines for nerve pain, and did not feel they meaningfully helped your symptoms
- You have a good enough understanding of English to take part in talk therapy (psychotherapy)
- If you are able to become pregnant, you are willing to use a highly effective or double-barrier form of birth control during the trial
Who may not be able to join:
- You have a history of addiction to or misuse of the drug Dextromethorphan
- A genetic test shows that your body is unable to process certain medications through a specific enzyme called CYP2D6 (confirm with trial site)
- You have certain mental health conditions, including a personal or family history of psychosis, bipolar disorder, borderline personality disorder, paranoid personality disorder, current thoughts of suicide, or a substance use problem within the past 12 months
- You are currently taking medications that may interact with the drugs used in this study (confirm with trial site)
- You have an unstable or poorly controlled medical condition, such as heart disease, liver disease, or severe kidney disease
- You have ever previously used a psychedelic drug that affects serotonin (such as psilocybin or LSD)
- You are currently pregnant or breastfeeding
- You have any other significant health condition that the study doctor believes could affect the results or put your health at risk
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Feasibility to recruit 30 participants into a trial of psilocybin and active placebo to prepare for a larger multicentre trial
Can't join this trial?
Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.