Gastro-oesophageal Reflux Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults between 41 and 84 years old who have never had an upper digestive tract camera examination (endoscopy) before and are able to give written consent to participate
- People who do not have ongoing heartburn or reflux symptoms and are not taking any regular medication for acid reflux or GERD
- People who meet medical guideline criteria for Barrett's esophagus screening, meaning they have at least three of the following risk factors: being white, having a BMI over 30 (obesity), being male, currently smoking or having smoked more than 10 pack-years, having a family history of Barrett's esophagus or esophageal cancer, having a waist size over 35 inches (women) or 40 inches (men), or having at least two family members with confirmed Barrett's esophagus or esophageal cancer (with at least one being a close relative)
- People who do not have a known bleeding disorder, are not taking regular blood-thinning medications, and do not have known varicose veins in the esophagus
- People who do not have significant trouble swallowing or pain when swallowing
Who may not be able to join:
- People who have had an upper digestive tract camera examination (endoscopy) within the past ten years
- People who are unable to provide written informed consent
- People who have had heartburn or regurgitation once a week or more for five or more years
- People who are on blood-thinning medications that cannot be safely stopped temporarily, or who have a bleeding disorder with certain abnormal blood test results (INR above 1.5)
- People with a known history of varicose veins in the esophagus or a narrowing of the esophagus (stricture)
- People for whom the treating investigator determines there is any medical reason that makes the study procedures unsafe, including conditions such as pouches in the esophagus (diverticula), an abnormal opening in the esophagus (fistula), or esophageal ulcers
- People with a history of difficulty swallowing or painful swallowing, including difficulty swallowing pills
- People with a tumour in the throat or mouth area
- People who have had surgery on the esophagus or stomach, except for certain uncomplicated reflux surgery where normal acid levels have been confirmed afterward (confirm with trial site)
- People who have had a heart attack or stroke within the past six months
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Katarina B Greer, MD/MS, Cleveland VA Research and Education Foundation
Phone: 216-791-3800
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Esoguard assay and histology confirming diagnosis of Barrett's esophagus and/or esophageal adenocarcinoma
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.