Gastro-oesophageal Reflux Disease

Who might be able to join this trial: - People who are 18 years of age or older at the time of joining the trial. - People who have been regularly taking any type of once-weekly GLP-1 medication (a type of injection used for diabetes or weight management) for at least one month before the trial begins. - People who are...

Who might be able to join this trial: - You have a known or suspected cancer in the food pipe (esophagus) or where the food pipe meets the stomach - You have been diagnosed with a condition called Barrett's metaplasia, where cells in the food pipe change in an abnormal way - You are being treated for symptoms of acid r...

**Who might be able to join this trial:** - You must be a patient eligible for care at the Kansas City VA Hospital, where this study is taking place. - You have been diagnosed with Barrett's esophagus (a condition affecting the lining of the food pipe), with or without abnormal cell changes, or you have acid reflux dis...

Who might be able to join this trial: - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis, a lung condition causing scarring) - People aged between 40 and 95 years old - People who are able to read, speak, and understand English - People who take medication for acid reflux or GERD (gastroesophageal...

Who might be able to join this trial: - People who are older than 18 years of age - People who experience typical acid reflux symptoms (such as heartburn or stomach contents coming back up into the throat) at least twice a week, even while taking acid-reducing medication called a PPI for at least one month - People who...

**Who might be able to join this trial:** - People who have had symptoms of acid reflux (GERD) — either in the oesophagus (such as heartburn) or in other areas like the throat or lungs — for more than 6 months - People who have had a test (endoscopy or pH-impedance study) confirming acid reflux or related oesophageal...

Who might be able to join this trial: - People who have had a lung transplant (single lung, double lung, or a repeat transplant) and whose lung function has been stable across their last two medical visits - People who had signs of acid reflux, abnormal swallowing test results, or stomach acid problems identified befor...

**Who might be able to join this trial:** **Group 1 (Aim 1 – people being screened for Barrett's Esophagus):** - Adults between the ages of 50 and 85 - People who have three or more known risk factors for a condition called Barrett's Esophagus - People who have been diagnosed with acid reflux disease, OR have taken ce...

**Who might be able to join this trial:** - People who are willing to take part and have signed a consent form agreeing to participate - People who have been diagnosed with gastroesophageal reflux disease (acid reflux), shown by at least weekly heartburn and/or regurgitation that has been ongoing for at least 3 months...

**Who might be able to join this trial:** - Infants who have had at least 2 regurgitation (spitting up) episodes per day over the past 2 weeks, and at least 4 regurgitation episodes per day on average over the last 2 days - Infants who are fed exclusively or mostly with formula (not breastfed, or mostly formula-fed) -...

**Who might be able to join this trial:** - People who have been clinically diagnosed with laryngopharyngeal reflux (LPR), which is a condition where stomach acid travels up to the throat - People who are 18 years of age or older (but under 65) - People whose symptom scores on two specific reflux questionnaires (calle...

Who might be able to join this trial: - Adults aged 18 years or older - People with a Body Mass Index (BMI) of 30 or higher (a measure of body weight relative to height that indicates obesity) - People who are able to give their own informed consent to take part in the procedure - People who do not have a stomach ulcer...

**Who might be able to join this trial:** - People with a Body Mass Index (BMI) over 35 kg/m² (a measure of body weight relative to height that indicates severe obesity) - People who have been following a medically supervised obesity treatment program for at least 2 years without significant weight loss - People who ar...

Who might be able to join this trial: - Adults aged 18 years or older who have been assessed as suitable for revision weight loss surgery that converts a sleeve gastrectomy to a gastric bypass. - People who are already scheduled to undergo this type of revision weight loss surgery. Who may not be able to join: - Peopl...

**Who might be able to join this trial:** - People who had a specific type of weight-loss surgery called OAGB (a form of gastric bypass) 10 years ago, roughly between 2009 and 2013, where a particular section of the intestine (either 150cm or 200cm) was used during the procedure - People who met the standard medical g...

Who might be able to join this trial: - People who are older than 18 years of age - People who have been considered as a candidate for weight-loss (bariatric) surgery - People who have obesity - People with a Body Mass Index (BMI) greater than 30 kg/m²(a number calculated from height and weight that doctors use to meas...

**Who might be able to join this trial:** - People aged 18 or older. - People who are scheduled to have a sleeve gastrectomy (a type of weight-loss stomach surgery) as their first weight-loss operation. - People with a Body Mass Index (BMI) of 35–40 who also have at least one serious health condition that surgery is l...

Who might be able to join this trial: - People who have been assessed by a doctor as needing a specific non-surgical procedure (called TIF, using a device called EsophyX) to treat long-term acid reflux disease. - People who are able to attend follow-up appointments at San Raffaele Hospital over a 5-year period after th...

Who might be able to join this trial: - People aged 18 or older, of any gender, who are willing to sign a consent form agreeing to take part in the study - People who have been diagnosed with achalasia (a condition affecting the ability to swallow) and have already had a procedure called POEM (a minimally invasive surg...

**Who might be able to join this trial:** - People who are older than 18 years of age - People diagnosed with a specific swallowing muscle disorder of the food pipe called "ineffective esophageal motility," identified using a standardised measurement system — this means that during a swallowing test, either 7 out of 10...

Who might be able to join this trial: - People aged 18 to 85 years old - People who have never had surgery before - People who have no symptoms related to the stomach or food pipe (esophagus), based on standard questionnaires - People who are not currently taking any medications that affect stomach acid or the movement...

**Who might be able to join this trial:** - People who had a specific type of weight-loss stomach surgery (called Roux-en-Y gastric bypass, using a particular stapling method) at least 12 months before the study - People who took acid-reducing medication (called a proton pump inhibitor) routinely for 6 months after th...

Who might be able to join this trial: - People between 21 and 65 years old - People who are able and willing to give their formal agreement to take part in the study - People whose pre-surgery camera examination of the throat and stomach showed a specific finding called "Hill's grade III" at the junction between the fo...

Who might be able to join this trial: - People between 5 and 21 years of age - People who receive more than 90% of their calories through a feeding tube and do not eat or drink by mouth - People who have been identified as being at high risk of aspiration pneumonia (where food or liquid enters the airway), based on a s...

Who might be able to join this trial: - People who currently live in the United States - People aged between 25 and 75 years old (including those ages) - People who can speak and read English - People who have not experienced unexplained weight loss, fevers, anaemia, or blood in their stool - People who are willing and...

Who might be able to join this trial: - People who are willing and able to give written consent to participate in the study. - Healthy men or women between 18 and 65 years of age. - People with a body mass index (BMI) between 18.5 and 35.0. - People and their partners who agree to follow the study's contraception requi...

**Who might be able to join this trial:** - You have a moderate-to-severe or severe leaky mitral heart valve (called mitral regurgitation) that is causing symptoms, OR you have a moderately leaky mitral valve combined with a narrowed mitral valve, along with calcium buildup around the valve - A specialist heart team a...

**Who might be able to join this trial:** - People who have had ongoing acid reflux symptoms — such as heartburn or regurgitation — at least twice a week for the past 6 months - People who have had a special acidity test (called an ambulatory pH study) that has confirmed acid reflux is occurring **Who may not be able...

**Who might be able to join this trial:** - People aged 18 to 85 years old - People diagnosed with gastroesophageal reflux disease (GERD — a condition where stomach acid flows back into the food pipe) who experience regurgitation (stomach contents coming back up) and symptoms in the throat or airways, such as burning...

Who might be able to join this trial: - The person must be 18 years of age or older. - The person has been diagnosed with gastroesophageal reflux disease (GERD), which is a condition where stomach acid flows back up into the throat or food pipe. - The person experiences symptoms such as ear, nose, or throat problems, a...

Who might be able to join this trial: - People who are scheduled to have a type of weight-loss surgery called a laparoscopic sleeve gastrectomy (where part of the stomach is removed to reduce its size) Who may not be able to join: - People under 18 years of age - People who are using anti-reflux medication for reasons...

**Who might be able to join this trial:** - Babies born before 32 weeks of pregnancy, assessed between 34 and 44 weeks of corrected age (counting from the original due date) - Babies who have been on a breathing machine (either through a tube in the airway, or through a mask or nasal prongs) for at least 48 hours at t...

**Who might be able to join this trial:** - People who have been diagnosed with gastroesophageal reflux disease (GERD) — a condition where stomach acid flows back into the food pipe — and still have symptoms despite taking acid-reducing medications called PPIs, want to stop taking PPIs, or cannot tolerate them - Peopl...

Who might be able to join this trial: - People who are willing and able to give informed consent and take part in the study. - People who are 18 years of age or older (or the legal age of adulthood in their country, if that is older than 18). - People who have had documented gastroesophageal reflux disease (acid reflux...

Who might be able to join this trial: - People who have been recommended to have a procedure called POEM (an internal muscle-cutting procedure done through an endoscope) for a swallowing condition called achalasia. - People with any type of achalasia whose symptoms score above 3 on a standard symptom scale called the E...

Who might be able to join this trial: - People who are 18 years of age or older - People who are willing and able to give informed consent to participate - People who are willing and able to attend follow-up visits and complete surveys over a longer period of time - People who have a Type II, III, or IV hiatal hernia l...

Who might be able to join this trial: - People whose main symptoms are heartburn or acid coming back up into the throat (gastroesophageal reflux disease symptoms) - People who are able to understand and sign a consent form agreeing to take part in the trial Who may not be able to join: - People who have previously bee...

Who might be able to join this trial: - People who are 2 years of age or older. - People who have symptoms or complaints of coughing. - People where the appropriate consent forms have been signed — by the person themselves if aged 18 or over, by a parent or legal guardian along with the person if aged 16 or 17, or by b...

Who might be able to join this trial: - Babies born before 31 weeks of pregnancy - Babies born before 37 weeks of pregnancy who have significant breathing or brain-related health problems - Babies who experienced a lack of oxygen around the time of birth Who may not be able to join: - Cases where a parent or guardian...

**Who might be able to join this trial:** - Adults between 18 and 65 years old who have been diagnosed with symptomatic achalasia type I or II (a swallowing condition where the food pipe has difficulty moving food into the stomach) - People who are able to understand the study requirements, complete certain questionnai...

Who might be able to join this trial: - Adults between 18 and 80 years of age - People who have had a specific reflux monitoring test (called pH-MII) done while not taking acid-reducing medications known as PPIs (proton pump inhibitors) Who may not be able to join: - People whose previous camera examination of the upp...

**Who might be able to join this trial:** - Babies who are currently in a neonatal intensive care unit (NICU) and are between 37 and 47 weeks of postmenstrual age (this is the baby's age calculated from the mother's last menstrual period) at the time the study begins - Babies who have been diagnosed with gastroesophage...

**Who might be able to join this trial:** - People who are a patient of a GP (general practitioner) who is taking part in the trial. - People who are at least 18 years old. - People who have been taking a PPI (a type of medication that reduces stomach acid) every day for at least 8 weeks. - People who are taking one of...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with dyspepsia (indigestion) - People who arrive at the emergency department with upper abdominal pain rated at least 3 out of 10 on a pain scale Who may not be able to join: - People who have a known aller...

Who might be able to join this trial: - Babies who have been diagnosed with gastroesophageal reflux disease (GERD), which is a condition where stomach contents come back up into the food pipe - Babies who were referred to the trial before their first birthday - Babies who are older than 1 month at the time treatment be...

Who might be able to join this trial: - Adults between 18 and 50 years of age - People who are able to understand and agree to participate in the study on their own - People with a Body Mass Index (a measure of body weight relative to height) below 30 - People whose hiatal defect (a gap where the stomach can push up th...

Who might be able to join this trial: - Babies who were born full-term (between 37 and 41 weeks of pregnancy) - Babies whose birth weight is normal for their age - Babies who scored higher than 8 on the APGAR health check (a standard newborn assessment) at 10 minutes after birth - Babies who had a normal physical exami...

**Who might be able to join this trial:** - People over 18 years old who have symptoms of gastroesophageal reflux disease (GERD — commonly known as acid reflux or heartburn) that have not improved enough after taking acid-reducing medications called proton pump inhibitors (PPIs) for at least 8 weeks. - People who have...

**Who might be able to join this trial:** - People aged between 18 and 60 years old - People who have a small hiatal hernia (a condition where part of the stomach slides into the chest) of 2 cm or less - People whose hernia is the "sliding" type and measures 2 cm or less - People whose acid reflux (GERD) symptoms come...

Who might be able to join this trial: - People aged between 21 and 65 years old - People who are having a routine screening colonoscopy, or a diagnostic camera examination of the upper digestive tract to investigate acid reflux or stomach discomfort, at NYU Langone Brooklyn Hospital Who may not be able to join: - Peop...

Who might be able to join this trial: - Babies who have at least one of certain common digestive problems (such as frequent spitting up, colic, or constipation), as defined by adapted Rome IV guidelines (confirm with trial site for specific definitions) - Babies who were born at 35 weeks of pregnancy or later - Babies...

Who might be able to join this trial: - People who are 18 years of age or older - People who are willing and able to give their consent to participate - People who are currently being assessed or tested for gastroesophageal reflux (a condition where stomach acid flows back into the food pipe) using standard medical pro...

**Who might be able to join this trial:** - Babies who were born before 32 weeks of pregnancy - Babies who are currently between 36 and 65 weeks post-menstrual age (the age calculated from the mother's last period before pregnancy) - Babies who have been diagnosed with bronchopulmonary dysplasia (a lung condition affe...

**Who might be able to join this trial:** - People between the ages of 17 and 60 years old - People of any gender - People who score 8 or higher on a standard GERD symptom questionnaire (called the GERD-Q), which is used to confirm a diagnosis of acid reflux disease **Who may not be able to join:** - People who have a...

Who might be able to join this trial: - People aged between 18 and 60 years old - People who have been diagnosed with GERD (acid reflux disease) by their doctor - People who have a spinal curvature (rounded upper back) with an angle greater than 30 degrees, as measured by a medical professional - People who score 8 or...

Who might be able to join this trial: - People aged between 22 and 75 years old (male or female) - People who have experienced at least three episodes of heartburn and/or acid reflux per week over the past three months - People who have had a specific acid monitoring test (either a wireless "Bravo" test or a tube-based...

Who might be able to join this trial: - Children between 2 and 18 years old who have been diagnosed with Cystic Fibrosis (CF), confirmed either by a sweat test or by having 2 known CF-causing gene changes - A parent or guardian (and the child if old enough) must be willing to sign a consent form agreeing to take part...

Who might be able to join this trial: - Women who are pregnant and scheduled for a planned (non-emergency) caesarean section - Between 18 and 40 years of age - Classified as having a moderate level of health risk for surgery (a medical rating system called ASA class II or III — confirm with trial site if unsure what th...

**Who might be able to join this trial:** - People aged 18 or older - People who have had a type of weight loss surgery called a one anastomosis gastric bypass, followed by a procedure called fundoplication (a surgery to treat severe acid reflux using the excluded part of the stomach), within the 2 years before joining...

Who might be able to join this trial: - People who have had ongoing acid reflux or heartburn symptoms (at least twice a week) for the past 6 months or more - People whose reflux has been confirmed by a pH study, which is a test that measures acid levels in the oesophagus over a period of time - People who have been pre...

Who might be able to join this trial: - People who have experienced a traumatic injury that is relevant to the trial's focus Who may not be able to join: - People whose traumatic injury is life-threatening and requires immediate medical treatment - People who are under 18 years of age (confirm with trial site for exac...

Who might be able to join this trial: - Women between 15 and 50 years of age - People who are currently pregnant or were recently pregnant - People who agree to take part in the study - People who agree to allow their healthcare provider(s) to share their health information with the registry - For the exposed group: pe...

Who might be able to join this trial: - People who are able to sign and date a consent form. - People who are willing to follow all study procedures and are available for the whole duration of the study. - People who have 3 or more established risk factors for Barrett's Oesophagus (a condition affecting the food pipe),...

**Who might be able to join this trial:** - Adults between 41 and 84 years old who have never had an upper digestive tract camera examination (endoscopy) before and are able to give written consent to participate - People who do not have ongoing heartburn or reflux symptoms and are not taking any regular medication fo...

Who might be able to join this trial: - People aged between 18 and 75 years old - People who have at least one of the following symptoms: upper abdominal pain, bloating, loss of appetite, acid reflux, or constipation - People who are already taking a medicine called Danning Tablets as part of their regular treatment fo...

**Who might be able to join this trial:** - People aged between 21 and 65 years old - People who are scheduled to have a laparoscopic sleeve gastrectomy (a type of weight-loss stomach surgery) at one of the participating hospitals - People who are able to understand and agree to take part by signing a consent form **W...

**Who might be able to join this trial:** - People aged between 18 and 75 years who are alert and able to understand and sign a consent form. - People who have long-term esophageal (food pipe) symptoms linked to how the brain and gut communicate with each other, such as heartburn, acid reflux, the feeling of something...

Who might be able to join this trial: - People who are between 18 and 65 years old, of any gender - People with a body mass index (BMI) between 35 and 55 (a measure of body weight relative to height) - People whose BMI falls within that range both before and after completing 6 months of non-surgical weight management a...

Who might be able to join this trial: - Adults between 18 and 50 years of age - People with no stomach or digestive symptoms - People who have not had any surgery on the stomach, intestines, chest, or spine in the past - People who are not taking any medications - People who have not consumed any alcohol in the past mo...

**Who might be able to join this trial:** - People aged between 18 and 75 years who are mentally alert and willing to sign a consent form. - People who have long-lasting esophageal (food pipe) symptoms thought to be related to how the brain and gut communicate with each other — such as heartburn, acid reflux, the feeli...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have had reflux esophagitis (irritation and inflammation of the food pipe caused by stomach acid) confirmed by a camera examination of the stomach, graded as moderate to severe (LA grade B, C, or D) - People who have been experiencing hear...

Who might be able to join this trial: - Adults aged 18 or older - People who have previously had a procedure called POEM (Per-Oral Endoscopic Myotomy) to treat a swallowing condition called achalasia - People who had a camera examination of their food pipe 3 months after POEM that showed a moderate to severe level of a...

**Who might be able to join this trial:** - Adults between 18 and 75 years old (male or female) - People experiencing ongoing heartburn and/or regurgitation (with or without stomach pain or burning) that is at least mild to moderate in severity, or that has occurred during the 7 days before the start of the study, as...

Who might be able to join this trial: - People who have been diagnosed with acid reflux disease (GERD) or a related condition (NERD) through a camera examination of the stomach, done within the last 15 days. - People who have had a specific test measuring acid and fluid movement in the food pipe (called impedance pHmet...

**Who might be able to join this trial:** - People aged 18 to 89 years old - People who have had throat or voice symptoms — such as coughing, frequent throat clearing, or a hoarse or changed voice — lasting more than 8 weeks - People who are scheduled to undergo a standard camera examination of the throat and food pipe...

**Who might be able to join this trial:** - People who are willing to read and sign a consent form before any study activities begin. - People aged 18 to 80 years old at the time of signing the consent form. - People who are able and willing to follow all parts of the study, including attending camera examinations of...

Who might be able to join this trial: - You are between 18 and 90 years old - You have never been officially diagnosed with heart failure (including any type of reduced or preserved heart pumping function), high blood pressure in the lungs (pulmonary hypertension), or a heart valve disease - You are able to understand...

**Who might be able to join this trial:** - People aged 18 or older - People who still have ongoing heartburn and/or regurgitation symptoms despite taking a standard acid-reducing medication (called a PPI) for at least 8 weeks **Who may not be able to join:** - People whose heartburn or reflux symptoms come with warni...

Who might be able to join this trial: - People aged 18 years or older - People who are willing and able to give informed consent to participate - People with gastro-oesophageal reflux disease (acid reflux) that is not well controlled by medication, or who cannot tolerate the medication, and who are being considered for...

**Who might be able to join this trial:** - People aged 18 years or older - People who have given written agreement to take part in the study - People who are being seen as outpatients or are admitted to a participating research centre **Who may not be able to join:** - People who do not wish to take part in the study...

**Who might be able to join this trial:** - People who are willing to take part and have signed a written consent form - People whose blood sugar levels are stable and well-controlled - People whose diabetes treatment (such as metformin, certain tablets, or insulin) has not changed — including no new medications added...

Who might be able to join this trial: - People who are 18 years of age or older - People who experience typical acid reflux symptoms, such as heartburn or regurgitation (the sensation of stomach contents coming back up) - People who own a smartphone and are able to use apps on it Who may not be able to join: - People...

**Who might be able to join this trial:** - People who have been diagnosed with gastroesophageal reflux disease (GERD), which is a condition where stomach acid regularly flows back into the food pipe, causing discomfort - People who scored more than 8 on a specific questionnaire used to measure reflux symptoms (called...

"Who might be able to join this trial: - People who are scheduled to have a type of weight loss surgery called a one anastomosis gastric bypass Who may not be able to join: - People who have not given their consent to participate in the trial Important: Always verify eligibility with the trial site directly before ap...

**Who might be able to join this trial:** - Infants aged 0 to 24 months old at the time of joining the trial - Infants who have been assessed by a clinician as having functional gut symptoms, such as colic, irritability, spitting up, constipation, or loose stools, and who a clinician considers suitable for the study -...

**Who might be able to join this trial:** *For the N-Sleeve Gastrectomy or Gastric Bypass groups:* - People who are 18 years of age or older - People who are willing and able to provide written consent to participate - People whose body weight meets national guidelines for weight-loss surgery — specifically, a BMI of...

Who might be able to join this trial: - People who have ongoing esophageal (food pipe) symptoms — such as heartburn, acid reflux, or difficulty swallowing — and are already scheduled to have an upper endoscopy (a camera test of the food pipe and stomach). Who may not be able to join: - People who have a narrowing or b...

Who might be able to join this trial: - People between 18 and 85 years of age. - People who have been diagnosed with a hiatal hernia (a condition where part of the stomach pushes up through the diaphragm into the chest), including any type from mild to severe. - People whose acid reflux (heartburn) symptoms have not im...

Who might be able to join this trial: - People who are at least 18 years old - People who are willing and able to give their consent to take part in the study - People who have been diagnosed with heart valve disease through an ultrasound of the heart (echocardiography), and whose results meet specific measurements sho...

**Who might be able to join this trial:** - Adults aged 19 years or older who are Korean residents, as of the date of signing consent - People who have been diagnosed with erosive gastroesophageal reflux disease (a condition where stomach acid damages the lining of the food pipe) confirmed by a camera examination of th...

**Who might be able to join this trial:** - Adults aged 18 or older (male or female) - People who have stopped taking a proton pump inhibitor (a type of stomach acid-reducing medication) after using it daily for at least 8 weeks, where that medication was no longer considered necessary based on current medical guideli...

Who might be able to join this trial: - People who are older than 18 years of age - People who have varicose veins that have been classified by doctors as falling within a specific range of severity (known as CEAP clinical class C2 to C6, which covers visible varicose veins through to active leg ulcers — confirm with t...

Who might be able to join this trial: - Children who are 8–9 years old or 12–13 years old - Children who are able to attend school Who may not be able to join: - Children who have a condition affecting both their physical movement and mental processing abilities (sometimes called psychomotor impairment) Important: Al...

Who might be able to join this trial: - Adults aged 18 or older - People who have been diagnosed with Type 2 Diabetes - People who have been taking a GLP-1 analog medication for more than 3 months - People who have signed a consent form agreeing to take part - People with an ASA physical status classification between I...

Who might be able to join this trial: - People who are willing and able to give their informed consent to take part in the study - People whose procedures are already part of their standard medical care, or who are already taking the relevant medication as part of their normal clinical treatment - People aged 18 years...

**Who might be able to join this trial:** - People aged between 20 and 80 years old. - People with a confirmed diagnosis of gastroesophageal reflux disease (GERD — a condition where stomach acid regularly flows back into the food pipe), confirmed by at least one of the following: - An internal camera examination (endo...

Who might be able to join this trial: - People between 18 and 80 years of age - People who have had acid reflux (GERD) symptoms, including troublesome regurgitation (stomach contents coming back up), for more than 6 months, even while taking at least 40 mg of acid-reducing medication (called a PPI) daily - People whose...

**Who might be able to join this trial:** - People who have been diagnosed with GERD (gastroesophageal reflux disease, also known as chronic acid reflux) - People who are in generally stable health with no current serious complications - People who are currently taking a stable, regular dose of a acid-reducing medicati...

**Who might be able to join this trial:** - People who have been diagnosed with gastroesophageal reflux disease (acid reflux), with typical symptoms such as heartburn and/or regurgitation lasting at least 6 months before the screening visit, as confirmed by the investigator - People who have had a camera test of the u...

Who might be able to join this trial: - People who have been confirmed through a biopsy to have a specific type of stomach cancer called gastric adenocarcinoma - People whose cancer is located in the upper part of the stomach, or at the junction where the food pipe meets the stomach (a specific category called Siewert...

Who might be able to join this trial: - People who are 20 years of age or older at the time of signing the consent form (confirm with trial site) - People whose symptoms of acid reflux or heartburn score 8 or higher on a specific questionnaire called the GerdQ, assessed at the first visit - People who choose to take pa...

**Who might be able to join this trial:** - People who have been diagnosed with gastroesophageal reflux disease (acid reflux), with typical symptoms such as heartburn and/or regurgitation lasting at least 6 months before the screening visit, as confirmed by the trial doctor. - People who have had a stomach camera test...

Who might be able to join this trial: - Children who have been diagnosed with gastroesophageal reflux disease (GERD), also known as chronic acid reflux, and are between 2 years old and 18 years old Who may not be able to join: - Children who have previously had surgery to treat acid reflux or related conditions - Chil...

Who might be able to join this trial: - People between 18 and 90 years of age - People who have been diagnosed with a hiatal hernia (where part of the stomach pushes up through the diaphragm) for the first time, confirmed by a camera examination of the stomach and/or an X-ray swallow test - People who are experiencing...

**Who might be able to join this trial:** - People who are 21 years of age or older - People who have been diagnosed with severe degenerative mitral regurgitation (a serious heart valve problem where the mitral valve leaks significantly), confirmed by an ultrasound of the heart - People whose mitral valve leaflets (the...