Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with colorectal cancer (bowel cancer) confirmed through a tissue or cell sample
• People who have at least one tumour that can be measured on a scan
• People aged between 18 and 70 years old, of any gender
• People whose cancer has continued to grow or spread after standard first-line treatment, and where it has been more than 2 weeks since their last cancer treatment ended
• People whose doctors expect them to live for at least 3 months
• People who are generally well enough to carry out light activity and care for themselves (a standard measure doctors use to rate overall health and activity level)
• Women who could become pregnant must have a negative pregnancy test and must agree to use effective contraception, with no plans for pregnancy during the 6 months of the study
• People who are able to complete all the blood tests and checks required during the screening period
• People whose heart, liver, and kidneys are functioning normally
• People whose blood test results fall within specific ranges for white blood cells, red blood cells, platelets, liver enzymes, kidney function, and blood clotting (confirm exact values with the trial site)
• People who do not have active hepatitis, HIV/AIDS, syphilis, or other active infectious diseases
• People whose inflammation-related blood markers (such as CRP, ASO, and a measure of how fast red blood cells settle) are within specified normal ranges (confirm with trial site)
• People whose thyroid hormone levels fall within specific normal ranges as measured by blood tests (confirm with trial site)
• People whose stress hormone levels (ACTH) fall within a specific normal range (confirm with trial site)
• People who are able to understand the study and are willing to sign a consent form

Who may not be able to join:

• People who have brain metastases (cancer that has spread to the brain) that are not well controlled
• People who are expected to need any other cancer treatment during the study, including chemotherapy, maintenance drug therapy, or surgery
• People who have taken steroid tablets or other immune-suppressing medicines at higher doses within the 14 days before the first study dose (inhaled or skin-applied steroids may be acceptable in some cases — confirm with trial site)
• People who have received certain immune-based cancer treatments (such as interferons, interleukins, thymosin, or immune cell therapies) within the 3 months before the first study dose
• People who are currently in another clinical trial, or whose last dose from a previous clinical trial was less than 4 weeks (or 5 half-lives of the previous study drug) before starting this one
• People who have had serious heart or blood vessel problems — such as a heart attack or stroke — within 3 months before the first dose, or unstable heart rhythm or unstable chest pain within 1 month before starting
• People with uncontrolled reduced blood flow to the heart or poorly controlled irregular heartbeat
• People with high blood pressure that remains uncontrolled despite medication (above 150/100 mmHg)
• People who have had significant bleeding episodes or have tumours that may be close to major blood vessels and at risk of causing serious bleeding, or who have coughed up 2.5 mL or more of blood in the month before the first dose
• People who have had a blood clot event — such as a stroke, mini-stroke, blood clot in a deep vein, or clot in the lungs — within 3 months before screening
• People with active tuberculosis
• People who have had a serious infection (such as one requiring a hospital stay, blood infection, or severe pneumonia) within 4 weeks before the first dose, or who have any currently active infection
• People who have had, or are preparing to have, an organ or tissue transplant
• People with uncontrolled epilepsy, central nervous system disorders, or neurological conditions affecting thinking and memory
• People who have had their spleen removed
• Women who are pregnant or breastfeeding
• People with a history of severe allergies or a tendency toward allergic reactions
• People who have had issues with alcohol or drug misuse in the 6 months before joining the study
• People the trial doctor considers unsuitable for the study for any other reason

Important: Always verify eligibility with the trial site directly before applying.