Colorectal Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with colorectal cancer (bowel cancer) confirmed by a tissue or cell test
• People who have at least one tumour that can be measured on a scan
• People aged between 18 and 70 years old, of any gender
• People whose cancer has continued to grow or spread after receiving two standard lines of treatment, and who have finished their last cancer treatment at least 2 weeks before joining
• People who are expected to live for at least 3 months
• People who are relatively well and able to carry out daily activities with little or no limitation (as assessed by a standard medical scale called ECOG 0–1)
• Women of childbearing age who have a negative pregnancy test and are willing to use effective contraception, with no plans to become pregnant within six months of being in the study
• People who are able to complete all the required blood and laboratory tests during the screening period
• People whose heart, liver, and kidney are functioning normally
• People whose blood test results fall within acceptable ranges, including healthy levels of white blood cells, red blood cells, platelets, and normal liver and kidney function markers (confirm specific values with trial site)
• People who do not have active hepatitis, HIV/AIDS, syphilis, or other active infectious diseases
• People whose inflammation markers (such as CRP, ASO, and erythrocyte sedimentation rate) fall within acceptable ranges (confirm specific values with trial site)
• People whose thyroid hormone levels are within the normal ranges required by the trial (confirm specific values with trial site)
• People whose adrenal hormone (ACTH) levels fall within the required range (confirm specific values with trial site)
• People who are able to understand the study and are willing to sign a consent form of their own free will

Who may not be able to join:

• People who have brain metastases (cancer that has spread to the brain) that cannot be controlled
• People who are expected to need any other cancer treatment during the study, including chemotherapy, maintenance drug therapy, or surgery
• People who have needed high-dose steroid tablets or other immune-suppressing medicines within the 14 days before starting the trial (inhaled or skin-applied steroids may be acceptable in some cases — confirm with trial site)
• People who have received certain immunotherapy or immune-stimulating cancer treatments within the 3 months before starting the trial
• People who are currently taking part in another clinical trial, or who finished a previous clinical trial less than 4 weeks (or 5 half-lives of that study drug) before starting this one
• People who have had serious heart or blood vessel problems — such as a heart attack, stroke, or unstable heart rhythm — within the past 1 to 3 months before starting the trial
• People with uncontrolled reduced blood supply to the heart or uncontrolled irregular heart rhythms
• People with high blood pressure that remains uncontrolled despite medication (systolic above 150 mmHg or diastolic above 100 mmHg)
• People who have had significant or unexplained bleeding within the 3 months before joining, or whose tumour is considered likely to involve or invade a major blood vessel, or who have coughed up a meaningful amount of blood in the month before starting
• People who have had a blood clot event — such as a stroke, mini-stroke, deep vein thrombosis, or pulmonary embolism — within the 3 months before screening
• People with active tuberculosis
• People who have had a serious infection (such as one requiring hospitalisation or severe pneumonia) within the 4 weeks before starting, or who have any currently active infection
• People who are planning to have, or who have previously had, an organ or tissue transplant
• People with uncontrolled epilepsy, brain or nervous system disorders that affect thinking or cognition
• People who have had their spleen removed
• Women who are pregnant or breastfeeding
• People with a history of severe allergies or a strong tendency toward allergic reactions
• People who have had a problem with ongoing alcohol or drug misuse in the 6 months before enrolling
• People who the trial doctor considers unsuitable for the study for any other reason

Important: Always verify eligibility with the trial site directly before applying.