Phase 3 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 75 years old (inclusive).
• People with pancreatic cancer that has spread to other parts of the body, confirmed by a tissue or cell sample.
• People who have not previously received any systemic treatment (such as chemotherapy, targeted therapy, or immunotherapy), radiation, surgery, or experimental drugs for their metastatic pancreatic cancer; people who had chemotherapy before or after surgery for an earlier stage of the disease may still be considered if it has been more than 6 months since that treatment ended and the cancer came back or spread.
• People with a general health and activity level rated as 0, 1, or 2 on a standard medical scale (meaning able to carry out at least some daily activities, confirm with trial site).
• People whose doctors expect them to live for at least 3 months.
• People who have at least one measurable area of cancer spread that can be seen clearly and tracked on CT or MRI scans, meeting specific size requirements; in some cases, people whose spread is confirmed by tissue testing even if it doesn't meet the size requirement may also be considered (confirm with trial site).
• People whose blood counts and organ function results (including blood cells, liver, kidneys, and blood clotting) fall within the ranges required by the trial (confirm with trial site for specific values).
• Women who could become pregnant must have a negative pregnancy test before joining and must use highly effective contraception from the screening period until 6 months after the last dose; male participants whose partners could become pregnant must use highly effective contraception from the first dose until 6 months after the last dose.
• People who understand what the trial involves, are willing to follow the trial procedures, and are able to sign the consent form.

Who may not be able to join:

• People who are known to be allergic to the trial drugs, similar drugs, or their ingredients.
• People who have had another cancer in the past 5 years, except for certain fully cured skin cancers, early-stage thyroid cancer, or early-stage cervical cancer as specified by the trial.
• People with known cancer spread to the brain or the lining of the brain, except in certain tightly controlled cases where a single brain lesion is present and causing no symptoms.
• People whose cancer has spread to cover more than half of the liver; people with active hepatitis B or active hepatitis C infections meeting specific test thresholds.
• People who test positive for HIV.
• People currently receiving treatment for an active, uncontrolled infection (bacterial, viral, or fungal).
• People with a history of drug or alcohol misuse before screening.
• People with serious failure of major organs (such as the heart or lungs) that would make chemotherapy unsafe.
• People with a tendency to bleed, such as active stomach ulcers, or who have had blood in their stools or coughed up blood in the past 3 months.
• People with serious heart or blood vessel conditions, including severe heart failure, uncontrolled high blood pressure, serious abnormal heart rhythms, abnormal heart electrical readings of clinical concern, or a heart attack, stroke, or other significant cardiovascular event in the 6 months before starting the trial.
• People with significant uncontrolled fluid build-up in body cavities (such as the lungs, heart lining, or abdomen) that requires medical treatment; small amounts that do not need treatment may be considered after careful review.
• People with serious psychiatric conditions, past or present.
• People who have received an organ transplant.
• People who plan to use medications that are prohibited under the trial protocol during the screening or treatment periods.
• People with a history of misusing medications that affect mental state and who are unable to stop.
• People who have recently taken part in another clinical trial involving an experimental drug, within timeframes specified by the trial (confirm with trial site for exact timeframes).
• People who are pregnant or breastfeeding.
• People whom the trial investigator considers unable to follow the trial procedures or otherwise unsuitable for the trial.

Important: Always verify eligibility with the trial site directly before applying.