Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 75 years old.
• People who are able to give their voluntary agreement to participate after being fully informed about the trial.
• People who have been diagnosed with Major Depressive Disorder (MDD) or Persistent Depressive Disorder (a long-lasting form of depression), without psychotic features, confirmed by a specific structured interview tool.
• People whose depressive symptoms have not improved after at least one adequate antidepressant medication trial during their current episode of depression (sometimes called difficult-to-treat depression), as assessed using a standardised treatment history form.
• People whose depression scores at least 15 points on a specific depression rating scale called the HRSD-17, indicating a moderate-to-severe level of symptoms.
• People who have not changed their psychiatric medications or psychotherapy in the four weeks before joining the trial.
• People who are considered physically inactive based on a standard physical activity questionnaire (IPAQ-SF).
• People who are medically cleared to take part in structured exercise, as determined by a screening questionnaire called the Get Active Questionnaire.
• People who are able to follow and attend the treatment schedule required by the trial.

Who may not be able to join:

• People who have been diagnosed with Bipolar I or Bipolar II Disorder.
• People who have had a problem with substance use or alcohol (excluding caffeine or nicotine) in the past three months or currently, as defined by standard diagnostic criteria.
• People who are currently using illegal substances.
• People who are currently using cannabis.
• People who have a major unstable medical or neurological condition, such as uncontrolled diabetes or kidney problems.
• People whose depression symptoms are caused by a physical or medical condition (for example, a thyroid problem), as determined by their referring doctor.
• People who are considered at acute risk of suicide or whose life is at risk due to self-neglect.
• People who are pregnant, breastfeeding, or planning to become pregnant during the course of the trial.
• People who have a medical reason they cannot safely receive TMS (brain stimulation) or MRI, such as a personal history of epilepsy or seizures, a metallic implant in the head, or a pacemaker, as confirmed by specific safety screening tools.
• People who are unwilling to keep their current psychiatric medications and/or psychotherapy unchanged for the four weeks before and throughout the duration of the study.
• People who are taking more than 1 mg per day of lorazepam or an equivalent sedative medication.
• People who, in the opinion of the research team, have any other condition that could interfere with their ability to complete the study.
• People who are already physically active at a level that meets or exceeds the "minimally active" threshold on the physical activity questionnaire (IPAQ-SF).

Important: Always verify eligibility with the trial site directly before applying.