Phase 2 Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 60 years old (inclusive)
• You are any gender (male or female)
• You are currently experiencing a major depressive episode that has lasted at least 4 weeks but no longer than 2 years (confirmed using a standard diagnostic tool)
• Your body weight falls within a healthy to moderately overweight range (BMI between 18.5 and 35.99)
• Your depression symptoms score at least 18 on a standard depression rating scale called the MADRS
• You have been taking an FDA-approved antidepressant at a steady, therapeutic dose for at least 8 weeks
• If you are receiving talk therapy, the type and frequency has been stable for at least 4 weeks
• You have an anxiety disorder that is no more than moderate in severity and is not your main diagnosis
• If you are able to become pregnant, you are using an effective form of birth control
• You are able to complete all tasks required by the study

Who may not be able to join:

• You have already tried more than 2 antidepressant treatments (including medications or brain stimulation therapies) at proper doses during your current depressive episode without success
• You have ever been diagnosed with bipolar disorder or a schizophrenia-related condition
• You are considered at significant risk of suicide, or you have had suicidal behavior in the past year
• You have experienced psychotic symptoms (such as hallucinations or delusions) during your current depressive episode or in the past 6 months
• You currently have a substance use disorder (in the past month) — note that nicotine and caffeine use are allowed
• You have an unstable neurological condition such as seizures (except seizures only occurring in infancy), a degenerative neurological disease, or have had a stroke
• You have evidence of severe nerve damage in your hands or feet (confirm with trial site)
• You have a history of moderate to severe traumatic brain injury (such as a skull fracture or being unconscious for more than 10 minutes) or a spinal cord injury
• You have an unstable significant medical condition, such as high blood pressure that is not controlled (above 150/95 mmHg)
• You have a history of cancer that has not been in remission for at least the past 5 years
• You are currently taking anti-seizure medications or calcium channel blocker medications
• You currently have a severe chronic pain condition or regularly take pain medications including NSAIDs (like ibuprofen) or opioids
• You have any implanted electronic medical device (such as a pacemaker)
• You have received any brain stimulation treatment in the past month
• You have active skin sores or wounds on areas where electrodes would be placed
• You are currently pregnant or breastfeeding
• Your IQ is suspected to be below 80
• There is any other clinical reason the study doctor considers makes participation unsuitable

Important: Always verify eligibility with the trial site directly before applying.