Parkinson's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who live in British Columbia, Canada and have an active provincial medical services plan (MSP)
• People between 19 and 70 years of age
• People who have a chronic, non-progressive spinal cord injury with complete motor paralysis at or above the T6 level of the spine, OR people diagnosed with Multiple System Atrophy (parkinsonian type) — a condition affecting the nervous system (confirm with trial site)
• People who had their spinal cord injury or diagnosis more than 1 year ago, and who have had at least 6 months since any spinal surgery
• People with a spinal cord injury who meet a specific injury severity classification (AIS A or B), or people with Multiple System Atrophy who experience a significant drop in blood pressure when standing up
• People who are able and willing to attend all clinic visits and follow all study procedures
• People who can understand and communicate in English, or who have access to an appropriate interpreter as assessed by the study team
• People who do not have painful muscle or joint problems, unhealed broken bones, open pressure sores, or active infections that could interfere with testing
• People whose spinal cord injury-related health issues (such as muscle stiffness) are being stably managed
• Women who could become pregnant must not be currently pregnant, breastfeeding, or planning to become pregnant, and must have a confirmed negative pregnancy test before the study begins
• Women who could become pregnant must agree to use effective contraception during the trial and for at least 28 days after the study ends (abstinence is accepted)
• Men who are sexually active and whose partners could become pregnant must agree to use effective contraception during the trial and for at least 28 days after the study ends
• People who are willing to provide informed consent to participate

Who may not be able to join:

• People who depend on a ventilator (breathing machine) to breathe
• People with significant, unmanaged depression (based on a standard questionnaire score above 15) or ongoing substance misuse
• People taking any medication or receiving any treatment that the study doctor believes makes participation unsuitable for that person
• People who have an intrathecal baclofen pump (a device implanted in the spine to deliver muscle relaxant medication)
• People who have heart, lung, bladder, or kidney disease that is unrelated to their spinal cord injury, or who have kidney swelling (hydronephrosis) or blocking kidney stones
• People with a serious current health issue that the study doctor believes would negatively affect their ability to participate — examples include active urinary tract infections, a bone condition called heterotopic ossification, recent changes to certain antidepressant medications, severe muscle pain, pressure sores, or unstable diabetes
• People who have any metal implants (other than dental implants) in the skull, or who have a pacemaker, stimulator, or medication pump in the trunk of the body
• People who take more than 40mg of Baclofen (a muscle relaxant medication) per day
• People with severe anaemia or low blood volume, as shown by a blood test taken in the last six months
• People who are a member of the research team running this trial, or an immediate family member of someone on the team
• People who have previously had electrode implant surgery

Important: Always verify eligibility with the trial site directly before applying.