Phase 3 Multiple Sclerosis Trial, Recruiting NCT06846281 Sponsor: Novartis Pharmaceuticals Condition: Multiple Sclerosis
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Phase 3 Multiple Sclerosis Trial, Recruiting

NCT06846281
Recruiting Phase 3 🇦🇺 Australian site

voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice

Who may and may not be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who may be able to join

  • You are between 40 and 70 years old (inclusive)
  • You have been diagnosed with relapsing multiple sclerosis (RMS) based on the 2017 McDonald diagnostic guidelines
  • You are currently being treated with ocrelizumab (a common MS medication) at the standard dose as part of your regular care
  • Your MS symptoms have been stable for at least the past 30 days
  • Your doctor believes, or you prefer, that switching to the study drug (remibrutinib) would be appropriate for you

Who may not be able to join

Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.

  • You have been diagnosed with primary progressive multiple sclerosis (PPMS) according to the 2017 McDonald criteria
  • You have a significant history of other brain, nervous system, or neurological conditions
  • You have previously been diagnosed with a serious brain infection called Progressive Multifocal Leukoencephalopathy (PML), or you currently have symptoms that might suggest it (confirm with trial site)
  • You currently have an active and serious infection, such as a bacterial, viral, parasitic, or fungal infection
  • You have an active or ongoing immune system disease other than MS
  • You have a serious heart condition or significant abnormalities shown on a heart tracing (ECG) test
  • You are unable to have MRI scans
  • You have previously had a life-threatening reaction to an ocrelizumab infusion or injection

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026

Contact this trial

Phone: 1-888-669-6682

Australian sites

Novartis Investigative Site, Melbourne, Victoria
Novartis Investigative Site, Parkville, Victoria
Novartis Investigative Site, Liverpool,
Novartis Investigative Site, St Leonards,

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Registry
ClinicalTrials.gov
Start date
23 June 2025
Est. completion
24 July 2029

Where this trial is recruiting

🇦🇷 Argentina 🇦🇺 Australia 🇧🇪 Belgium 🇧🇷 Brazil 🇨🇦 Canada 🇨🇿 Czechia 🇩🇰 Denmark 🇫🇷 France 🇩🇪 Germany 🇬🇷 Greece 🇮🇹 Italy 🇲🇽 Mexico 🇵🇹 Portugal 🇸🇰 Slovakia 🇿🇦 South Africa 🇪🇸 Spain 🇨🇭 Switzerland 🇬🇧 United Kingdom 🇺🇸 United States

4 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Annualized rate of new or enlarging T2 lesions_Core Part

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov