Phase 2 Peripheral Neuropathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to take part in all trial activities and who can sign and date a consent form before any trial procedures begin
• People aged 18 to 75 years, of any gender
• People who have been diagnosed with a diabetic ulcer (wound related to diabetes) located on the top or bottom of the foot, or below the knee
• People whose wound is classified as a moderate-depth diabetic ulcer (Wagner grade 2) without a whole-body infection
• People whose largest wound is smaller than 25 square centimetres, and where all individual wounds are also smaller than that size
• People whose wound has been present for at least 12 weeks before joining the trial, and who have already been receiving standard wound care for at least 4 weeks
• People where there is at least 3 centimetres of clear skin between the main wound and any other wounds on the same foot (measured after wound cleaning)

Who may not be able to join:

• People with a known allergy to the ingredients of the trial gel (MDI-1228 mesylate), or to a class of medicines called JAK inhibitors (such as tofacitinib, baricitinib, or ruxolitinib), or people known to have a generally allergy-prone constitution
• People whose skin ulcer or chronic wound was caused by electric shock, chemical exposure, or radioactive material
• People whose main wound has already shrunk by 30% or more in the past 4 weeks while receiving standard care
• People who have a wound caused by cancer, or who have certain immune system or connective tissue conditions such as lupus, rheumatoid arthritis, or scleroderma

Important: Always verify eligibility with the trial site directly before applying.