Phase 1 Peripheral Neuropathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with Stage III colorectal cancer, confirmed through a tissue biopsy or similar laboratory test.
• People who are scheduled to receive a specific chemotherapy regimen called modified FOLFOX-6.
• People who have no medical reasons preventing them from receiving chemotherapy.
• People aged 18 years or older, of any gender.
• People whose blood test results show healthy enough levels of white blood cells, platelets, and red blood cells (confirm specific numbers with trial site).
• People whose kidneys are functioning adequately, based on a blood test result (confirm specific threshold with trial site).
• People whose liver is functioning adequately, based on a blood test result (confirm specific threshold with trial site).
• People who are in generally good physical condition, rated 0 or 1 on a standard oncology fitness scale, meaning they are fully active or have only minor limitations in physical activity.
• People who are able to take medications used to manage nerve pain caused by chemotherapy, such as gabapentin or similar drugs.

Who may not be able to join:

• People who have been treated with certain drugs known to damage nerves (such as cisplatin, vincristine, or paclitaxel) within the past 6 months.
• People who already show signs that the cancer has spread to other parts of the body at the time of their first assessment.
• People who are currently taking antioxidant vitamin supplements, including vitamins A, C, or E.
• People who already have nerve damage (peripheral neuropathy) caused by conditions such as diabetes, thyroid disorders, autoimmune diseases, or hepatitis C.
• People who have diabetes.
• People who have inflammatory conditions such as ulcerative colitis or rheumatoid arthritis.
• People who smoke or have conditions such as chronic obstructive pulmonary disease (a long-term lung condition) (confirm full list with trial site).
• People who have active liver disease, such as cirrhosis, fatty liver disease, or hepatitis C.
• People who have a muscle disease (myopathy).
• People who have reduced kidney function, including those with end-stage kidney disease or those receiving dialysis.
• Women who are pregnant or breastfeeding.
• People who are currently taking certain medications, including diltiazem, metoprolol, enalapril, nitroglycerin, warfarin, clopidogrel, aspirin, statins, fibrates, or tricyclic antidepressants (confirm full list with trial site).

Important: Always verify eligibility with the trial site directly before applying.