Atrial Fibrillation Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 80 years of age
• People who had a heart rhythm procedure (ablation for atrial fibrillation or atrial flutter) roughly 2 to 12 months ago (within a specific time window around that range)
• People with a heart stroke-risk score called CHA2DS2-VA of 2 or higher
• People with no history of stroke, mini-stroke (TIA), or blood clots travelling to other parts of the body
• People who have been taking a blood thinner called a NOAC continuously since their ablation procedure
• People who have had no recorded return of abnormal heart rhythms since their ablation
• People who have not taken heart rhythm medications (antiarrhythmic drugs) in the past 2 months
• People who are willing and able to give written consent to participate
• People who are willing and able to attend follow-up visits and complete study procedures

Who may not be able to join:

• People considered at high risk of their heart rhythm problem returning after ablation — for example, those whose heart monitoring showed a high number of early, irregular heartbeats (more than 3% on a recording)
• People with a significant narrowing of the mitral heart valve (mitral valve area of 2.0 cm² or less) or a mechanical heart valve
• People with an increased risk of serious bleeding, including any of the following:
  • Those currently experiencing a major or clinically significant bleeding episode
  • Those with a past history of serious non-injury-related bleeding (such as bleeding in the brain, eye, spine, gut, or joints) unless the cause has been permanently resolved
  • Those with an unresolved brain aneurysm or blood vessel abnormality, or an active stomach or bowel ulcer
  • Those who had major surgery requiring general anaesthesia within the past 3 months
  • Those who have major surgery planned within the next 3 months
  • Those with a known condition that causes abnormal bleeding (such as haemophilia)
  • Those with very high uncontrolled blood pressure (top number above 180 or bottom number above 110)
  • Those with low haemoglobin (below 90 g/L) or who received a blood transfusion in the past 4 weeks
  • Those with a very low platelet count (below 50 × 10⁹/L)
  • Those with severe kidney disease or who are on dialysis
  • Those with severe liver disease (for example, bleeding from the throat, fluid in the abdomen, confusion caused by liver failure, or yellowing of the skin)
  • Those known to be unable to tolerate or safely take blood thinning tablets
• People who need to stay on blood thinners for another medical reason, such as a blood clot in the lungs, a clot in a leg vein, or certain heart muscle conditions
• People with significant narrowing (70% or more) of major arteries supplying the brain, which raises the risk of a non-heart-related stroke
• People who have previously had a procedure to close or remove the left atrial appendage (a small pouch in the heart)
• People who are pregnant, breastfeeding, or of childbearing potential and not using effective contraception
• People with a life expectancy of less than 2 years
• People currently taking part in another interventional clinical trial
• People who the trial investigators judge to be unsuitable for the study for any other reason (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.